SIAH2

Seven in absentia homolog 2 (Drosophila)
Identifiers
Symbols	SIAH2 ; hSiah2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21053
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Seven in absentia homolog 2 (Drosophila), also known as SIAH2, is a human gene.

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Hu G, Zhang S, Vidal M; et al. (1997). "Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway". Genes Dev. 11 (20): 2701–14. PMID 9334332.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu G, Chung YL, Glover T; et al. (1998). "Characterization of human homologs of the Drosophila seven in absentia (sina) gene". Genomics. 46 (1): 103–11. doi:10.1006/geno.1997.4997. PMID 9403064.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu G, Fearon ER (1999). "Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins". Mol. Cell. Biol. 19 (1): 724–32. PMID 9858595.
• Germani A, Romero F, Houlard M; et al. (1999). "hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways". Mol. Cell. Biol. 19 (5): 3798–807. PMID 10207103.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Relaix F, Wei X, Li W; et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. doi:10.1073/pnas.040378897. PMID 10681424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Joensuu T, Hämäläinen R, Lehesjoki AE; et al. (2000). "A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q". Genomics. 63 (3): 409–16. doi:10.1006/geno.1999.6096. PMID 10704288.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsuzawa SI, Reed JC (2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol. Cell. 7 (5): 915–26. PMID 11389839.
• Boehm J, He Y, Greiner A; et al. (2001). "Regulation of BOB.1/OBF.1 stability by SIAH". EMBO J. 20 (15): 4153–62. doi:10.1093/emboj/20.15.4153. PMID 11483518.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wheeler TC, Chin LS, Li Y; et al. (2002). "Regulation of synaptophysin degradation by mammalian homologues of seven in absentia". J. Biol. Chem. 277 (12): 10273–82. doi:10.1074/jbc.M107857200. PMID 11786535.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kutsenko AS, Gizatullin RZ, Al-Amin AN; et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–70. PMID 12136098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Habelhah H, Frew IJ, Laine A; et al. (2002). "Stress-induced decrease in TRAF2 stability is mediated by Siah2". EMBO J. 21 (21): 5756–65. PMID 12411493.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okabe H, Satoh S, Furukawa Y; et al. (2003). "Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1". Cancer Res. 63 (12): 3043–8. PMID 12810624.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fanelli M, Fantozzi A, De Luca P; et al. (2004). "The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome". J. Biol. Chem. 279 (7): 5374–9. doi:10.1074/jbc.M306407200. PMID 14645235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Germani A, Prabel A, Mourah S; et al. (2004). "SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway". Oncogene. 22 (55): 8845–51. doi:10.1038/sj.onc.1206994. PMID 14654780.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama K, Frew IJ, Hagensen M; et al. (2004). "Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia". Cell. 117 (7): 941–52. doi:10.1016/j.cell.2004.06.001. PMID 15210114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)