PRPF3

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PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)
File:PBB Protein PRPF3 image.jpg
PDB rendering based on 1x4q.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols PRPF3 ; HPRP3; HPRP3P; PRP3; Prp3p; RP18
External IDs Template:OMIM5 Template:MGI HomoloGene: 3447
RNA expression pattern
File:PBB GE PRPF3 202251 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae), also known as PRPF3, is a human gene.[1]

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF3 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM][1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Xu SY, Schwartz M, Rosenberg T, Gal A (1997). "A ninth locus (RP18) for autosomal dominant retinitis pigmentosa maps in the pericentromeric region of chromosome 1". Hum. Mol. Genet. 5 (8): 1193–7. PMID 8842740.
  • Wang A, Forman-Kay J, Luo Y; et al. (1997). "Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome". Hum. Mol. Genet. 6 (12): 2117–26. PMID 9328476.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Horowitz DS, Kobayashi R, Krainer AR (1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMID 9404889.
  • Heng HH, Wang A, Hu J (1998). "Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33". Genomics. 48 (2): 273–5. doi:10.1006/geno.1997.5181. PMID 9521884.
  • Xu SY, Rosenberg T, Gal A (1998). "Refined genetic mapping of autosomal dominant retinitis pigmentosa locus RP18 reduces the critical region to 2 cM between D1S442 and D1S2858 on chromosome 1q". Hum. Genet. 102 (4): 493–4. PMID 9600251.
  • Reidt U, Reuter K, Achsel T; et al. (2000). "Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin". J. Biol. Chem. 275 (11): 7439–42. PMID 10713041.
  • Chakarova CF, Hims MM, Bolz H; et al. (2002). "Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa". Hum. Mol. Genet. 11 (1): 87–92. PMID 11773002.
  • Horowitz DS, Lee EJ, Mabon SA, Misteli T (2002). "A cyclophilin functions in pre-mRNA splicing". EMBO J. 21 (3): 470–80. PMID 11823439.
  • Gonzalez-Santos JM, Wang A, Jones J; et al. (2002). "Central region of the human splicing factor Hprp3p interacts with Hprp4p". J. Biol. Chem. 277 (26): 23764–72. doi:10.1074/jbc.M111461200. PMID 11971898.
  • Nottrott S, Urlaub H, Lührmann R (2002). "Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins". EMBO J. 21 (20): 5527–38. PMID 12374753.
  • Ajuh P, Chusainow J, Ryder U, Lamond AI (2003). "A novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing". EMBO J. 21 (23): 6590–602. PMID 12456665.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Martínez-Gimeno M, Gamundi MJ, Hernan I; et al. (2003). "Mutations in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31 in Spanish families with autosomal dominant retinitis pigmentosa". Invest. Ophthalmol. Vis. Sci. 44 (5): 2171–7. PMID 12714658.
  • Reidt U, Wahl MC, Fasshauer D; et al. (2003). "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". J. Mol. Biol. 331 (1): 45–56. PMID 12875835.
  • Wada Y, Itabashi T, Sato H, Tamai M (2005). "Clinical features of a Japanese family with autosomal dominant retinitis pigmentosa associated with a Thr494Met mutation in the HPRP3 gene". Graefes Arch. Clin. Exp. Ophthalmol. 242 (11): 956–61. doi:10.1007/s00417-004-0923-x. PMID 15085354.
  • Stanĕk D, Neugebauer KM (2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". J. Cell Biol. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMID 15452143.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (2005). "Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex". Exp. Cell Res. 302 (1): 61–8. doi:10.1016/j.yexcr.2004.08.022. PMID 15541726.

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