PRELP

Proline/arginine-rich end leucine-rich repeat protein
Identifiers
Symbols	PRELP ; MGC45323; MST161; MSTP161; SLRR2A
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2041
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PRELP 37022 at tn.png
File:PBB GE PRELP 204223 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Proline/arginine-rich end leucine-rich repeat protein, also known as PRELP, is a human gene.

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.

Further reading

• Lewis M (2003). "PRELP, collagen, and a theory of Hutchinson-Gilford progeria". Ageing Res. Rev. 2 (1): 95–105. PMID 12437997.
• Bengtsson E, Neame PJ, Heinegård D, Sommarin Y (1995). "The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues". J. Biol. Chem. 270 (43): 25639–44. PMID 7592739.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Grover J, Chen XN, Korenberg JR; et al. (1997). "The gene organization, chromosome location, and expression of a 55-kDa matrix protein (PRELP) of human articular cartilage". Genomics. 38 (2): 109–17. doi:10.1006/geno.1996.0605. PMID 8954791.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grover J, Roughley PJ (1999). "Characterization of the human proline/arginine-rich end leucine-rich repeat protein (PRELP) gene promoter and identification of a repressor element". Biochem. J. 336 ( Pt 1): 77–82. PMID 9806887.
• Bengtsson E, Mörgelin M, Sasaki T; et al. (2002). "The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor". J. Biol. Chem. 277 (17): 15061–8. doi:10.1074/jbc.M108285200. PMID 11847210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wistow G, Bernstein SL, Wyatt MK; et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Johnson JM, Young TL, Rada JA (2006). "Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP". Mol. Vis. 12: 1057–66. PMID 17093390.CS1 maint: Multiple names: authors list (link)
• Grover J, Lee ER, Mounkes LC; et al. (2007). "The consequence of PRELP overexpression on skin". Matrix Biol. 26 (2): 140–3. doi:10.1016/j.matbio.2006.10.005. PMID 17123807.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)