PPP2R5C

Protein phosphatase 2, regulatory subunit B', gamma isoform
File:PBB Protein PPP2R5C image.jpg PDB rendering based on 2iae.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2iae​, 2jak​, 2npp​, 2nyl​, 2nym​
Identifiers
Symbols	PPP2R5C ; B56G; MGC23064; PR61G
External IDs	Template:OMIM5 Template:MGI HomoloGene: 86888
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PPP2R5C 201877 s at tn.png
File:PBB GE PPP2R5C 213305 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein phosphatase 2, regulatory subunit B', gamma isoform, also known as PPP2R5C, is a human gene.

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMID 15725353.
• Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
• Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.CS1 maint: Multiple names: authors list (link)
• Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. PMID 7584026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nomura N, Nagase T, Miyajima N; et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. PMID 7584044.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McCright B, Virshup DM (1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J. Biol. Chem. 270 (44): 26123–8. PMID 7592815.
• Akiyama N, Shima H, Hatano Y; et al. (1995). "cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase". Eur. J. Biochem. 230 (2): 766–72. PMID 7607250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tehrani MA, Mumby MC, Kamibayashi C (1996). "Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle". J. Biol. Chem. 271 (9): 5164–70. PMID 8617797.CS1 maint: Multiple names: authors list (link)
• Zolnierowicz S, Van Hoof C, Andjelković N; et al. (1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". Biochem. J. 317 ( Pt 1): 187–94. PMID 8694763.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McCright B, Rivers AM, Audlin S, Virshup DM (1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. 271 (36): 22081–9. PMID 8703017.CS1 maint: Multiple names: authors list (link)
• McCright B, Brothman AR, Virshup DM (1997). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics. 36 (1): 168–70. PMID 8812429.CS1 maint: Multiple names: authors list (link)
• Tung HY, De Rocquigny H, Zhao LJ; et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. PMID 9013886.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.CS1 maint: Multiple names: authors list (link)
• Scanlan MJ, Gordan JD, Williamson B; et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. PMID 10508479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito A, Kataoka TR, Watanabe M; et al. (2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". EMBO J. 19 (4): 562–71. doi:10.1093/emboj/19.4.562. PMID 10675325.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikeda S, Kishida M, Matsuura Y; et al. (2000). "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin". Oncogene. 19 (4): 537–45. doi:10.1038/sj.onc.1203359. PMID 10698523.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMID 10921877.CS1 maint: Multiple names: authors list (link)
• Elder RT, Yu M, Chen M; et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Muneer S, Ramalingam V, Wyatt R; et al. (2002). "Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit". Genomics. 79 (3): 344–8. doi:10.1006/geno.2002.6721. PMID 11863364.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strack S, Ruediger R, Walter G; et al. (2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". J. Biol. Chem. 277 (23): 20750–5. doi:10.1074/jbc.M202992200. PMID 11929880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)