PARP4

Poly (ADP-ribose) polymerase family, member 4
Identifiers
Symbols	PARP4 ; ADPRTL1; PARPL; PH5P; VAULT3; VPARP; p193
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4699
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PARP4 202239 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Poly (ADP-ribose) polymerase family, member 4, also known as PARP4, is a human gene.

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.

Further reading

• Jean L, Risler JL, Nagase T; et al. (1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. PMID 10100603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soldani C, Scovassi AI (2003). "Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update". Apoptosis. 7 (4): 321–8. PMID 12101391.
• Bouchard VJ, Rouleau M, Poirier GG (2003). "PARP-1, a determinant of cell survival in response to DNA damage". Exp. Hematol. 31 (6): 446–54. PMID 12829019.CS1 maint: Multiple names: authors list (link)
• Soares MB, Bonaldo MF, Jelene P; et al. (1994). "Construction and characterization of a normalized cDNA library". Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9228–32. PMID 7937745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Seki N, Ishikawa K; et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. PMID 8724849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kickhoefer VA, Siva AC, Kedersha NL; et al. (1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". J. Cell Biol. 146 (5): 917–28. PMID 10477748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kickhoefer VA, Stephen AG, Harrington L; et al. (2000). "Vaults and telomerase share a common subunit, TEP1". J. Biol. Chem. 274 (46): 32712–7. PMID 10551828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Still IH, Vince P, Cowell JK (2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein". Genomics. 62 (3): 533–6. doi:10.1006/geno.1999.6024. PMID 10644454.CS1 maint: Multiple names: authors list (link)
• Siva AC, Raval-Fernandes S, Stephen AG; et al. (2001). "Up-regulation of vaults may be necessary but not sufficient for multidrug resistance". Int. J. Cancer. 92 (2): 195–202. PMID 11291045.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Zon A, Mossink MH, Schoester M; et al. (2001). "Multiple human vault RNAs. Expression and association with the vault complex". J. Biol. Chem. 276 (40): 37715–21. doi:10.1074/jbc.M106055200. PMID 11479319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Zon A, Mossink MH, Schoester M; et al. (2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID 11855821.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mazzon E, Dugo L, Li JH; et al. (2002). "GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat". Biochem. Pharmacol. 64 (2): 327–37. PMID 12123754.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu TJ, Lin SY, Chau YP (2002). "Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells". Toxicol. Appl. Pharmacol. 182 (2): 116–25. PMID 12140175.CS1 maint: Multiple names: authors list (link)
• Nie Z, Phenix BN, Lum JJ; et al. (2003). "HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation". Cell Death Differ. 9 (11): 1172–84. doi:10.1038/sj.cdd.4401094. PMID 12404116.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dunham A, Matthews LH, Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Y, Snow BE, Kickhoefer VA; et al. (2004). "Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo". Mol. Cell. Biol. 24 (12): 5314–23. doi:10.1128/MCB.24.12.5314-5323.2004. PMID 15169895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)