NUF2
| NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | NUF2 ; CDCA1; NUF2R | ||||||||||
| External IDs | Template:MGI HomoloGene: 41521 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae), also known as NUF2, is a human gene.[1]
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.[1]
References
Further reading
- Wigge PA, Kilmartin JV (2001). "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation". J. Cell Biol. 152 (2): 349–60. PMID 11266451.
- Nabetani A, Koujin T, Tsutsumi C; et al. (2002). "A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint". Chromosoma. 110 (5): 322–34. doi:10.1007/s004120100153. PMID 11685532.
- DeLuca JG, Moree B, Hickey JM; et al. (2003). "hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells". J. Cell Biol. 159 (4): 549–55. doi:10.1083/jcb.200208159. PMID 12438418.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Tien AC, Lin MH, Su LJ; et al. (2004). "Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model". Mol. Cell Proteomics. 3 (1): 93–104. doi:10.1074/mcp.M300072-MCP200. PMID 14602875.
- DeLuca JG, Howell BJ, Canman JC; et al. (2004). "Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores". Curr. Biol. 13 (23): 2103–9. PMID 14654001.
- Bharadwaj R, Qi W, Yu H (2004). "Identification of two novel components of the human NDC80 kinetochore complex". J. Biol. Chem. 279 (13): 13076–85. doi:10.1074/jbc.M310224200. PMID 14699129.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Joseph J, Liu ST, Jablonski SA; et al. (2004). "The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo". Curr. Biol. 14 (7): 611–7. doi:10.1016/j.cub.2004.03.031. PMID 15062103.
- Stucke VM, Baumann C, Nigg EA (2005). "Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1". Chromosoma. 113 (1): 1–15. doi:10.1007/s00412-004-0288-2. PMID 15235793.
- Meraldi P, Draviam VM, Sorger PK (2004). "Timing and checkpoints in the regulation of mitotic progression". Dev. Cell. 7 (1): 45–60. doi:10.1016/j.devcel.2004.06.006. PMID 15239953.
- Cheeseman IM, Niessen S, Anderson S; et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMID 15371340.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- DeLuca JG, Dong Y, Hergert P; et al. (2005). "Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites". Mol. Biol. Cell. 16 (2): 519–31. doi:10.1091/mbc.E04-09-0852. PMID 15548592.
- Ciferri C, De Luca J, Monzani S; et al. (2005). "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore". J. Biol. Chem. 280 (32): 29088–95. doi:10.1074/jbc.M504070200. PMID 15961401.
- Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
- Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
- Liu D, Ding X, Du J; et al. (2007). "Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment". J. Biol. Chem. 282 (29): 21415–24. doi:10.1074/jbc.M609026200. PMID 17535814.
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