NUDT1

Nudix (nucleoside diphosphate linked moiety X)-type motif 1
File:PBB Protein NUDT1 image.jpg PDB rendering based on 1iry.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1iry​
Identifiers
Symbols	NUDT1 ; MTH1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1839
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NUDT1 204766 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nudix (nucleoside diphosphate linked moiety X)-type motif 1, also known as NUDT1, is a human gene.

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Further reading

• Ponnambalam S, Jackson AP, LeBeau MM; et al. (1995). "Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB)". Genomics. 24 (3): 440–4. doi:10.1006/geno.1994.1650. PMID 7713494.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furuichi M, Yoshida MC, Oda H; et al. (1995). "Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion". Genomics. 24 (3): 485–90. doi:10.1006/geno.1994.1657. PMID 7713500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kang D, Nishida J, Iyama A; et al. (1995). "Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria". J. Biol. Chem. 270 (24): 14659–65. PMID 7782328.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakumi K, Furuichi M, Tsuzuki T; et al. (1993). "Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis". J. Biol. Chem. 268 (31): 23524–30. PMID 8226881.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oda H, Nakabeppu Y, Furuichi M, Sekiguchi M (1997). "Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products". J. Biol. Chem. 272 (28): 17843–50. PMID 9211940.CS1 maint: Multiple names: authors list (link)
• Oda H, Taketomi A, Maruyama R; et al. (1999). "Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism". Nucleic Acids Res. 27 (22): 4335–43. PMID 10536140.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsuzuki T, Egashira A, Igarashi H; et al. (2001). "Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11456–61. doi:10.1073/pnas.191086798. PMID 11572992.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakai Y, Furuichi M, Takahashi M; et al. (2002). "A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1". J. Biol. Chem. 277 (10): 8579–87. doi:10.1074/jbc.M110566200. PMID 11756418.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujikawa K, Yakushiji H, Nakabeppu Y; et al. (2002). "8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog". FEBS Lett. 512 (1–3): 149–51. PMID 11852070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Topp H, Armbrust S, Lengger C; et al. (2002). "Renal excretion of 8-oxo-7,8-dihydro-2(')-deoxyguanosine: degradation rates of RNA and metabolic rate in humans". Arch. Biochem. Biophys. 402 (1): 31–7. doi:10.1016/S0003-9861(02)00034-6. PMID 12051680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi M, Maraboeuf F, Sakai Y; et al. (2002). "Role of tryptophan residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein". J. Mol. Biol. 319 (1): 129–39. PMID 12051941.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Z, Wang LE, Strom SS; et al. (2003). "Overexpression of hMTH in peripheral lymphocytes and risk of prostate cancer: a case-control analysis". Mol. Carcinog. 36 (3): 123–9. doi:10.1002/mc.10108. PMID 12619034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishibashi T, Hayakawa H, Sekiguchi M (2004). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Rep. 4 (5): 479–83. doi:10.1038/sj.embor.embor838. PMID 12717453.CS1 maint: Multiple names: authors list (link)
• Kennedy CH, Pass HI, Mitchell JB (2004). "Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue". Free Radic. Biol. Med. 34 (11): 1447–57. PMID 12757855.CS1 maint: Multiple names: authors list (link)
• Yoshimura D, Sakumi K, Ohno M; et al. (2003). "An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress". J. Biol. Chem. 278 (39): 37965–73. doi:10.1074/jbc.M306201200. PMID 12857738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamiya H, Dugué L, Yakushiji H; et al. (2003). "Substrate recognition by the human MTH1 protein". Nucleic Acids Res. Suppl. (2): 85–6. PMID 12903117.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bialkowski K, Kasprzak KS (2004). "Inhibition of 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity of the antimutagenic human MTH1 protein by nucleoside 5'-diphosphates". Free Radic. Biol. Med. 35 (6): 595–602. PMID 12957652.
• Kamiya H, Yakushiji H, Dugué L; et al. (2004). "Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs". J. Mol. Biol. 336 (4): 843–50. doi:10.1016/j.jmb.2003.12.060. PMID 15095864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)