LTK (gene)

Leukocyte tyrosine kinase
Identifiers
Symbols	LTK ; TYK1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37613
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LTK 207106 s at tn.png
File:PBB GE LTK 217184 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Leukocyte tyrosine kinase, also known as LTK, is a human gene.

The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Further reading

• Krolewski JJ, Dalla-Favera R (1991). "The ltk gene encodes a novel receptor-type protein tyrosine kinase". EMBO J. 10 (10): 2911–9. PMID 1655406.
• Krolewski JJ, Lee R, Eddy R; et al. (1990). "Identification and chromosomal mapping of new human tyrosine kinase genes". Oncogene. 5 (3): 277–82. PMID 2156206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maru Y, Hirai H, Takaku F (1990). "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res. 5 (3): 199–204. PMID 2320375.CS1 maint: Multiple names: authors list (link)
• Ben-Neriah Y, Bauskin AR (1988). "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain". Nature. 333 (6174): 672–6. doi:10.1038/333672a0. PMID 2836739.
• Toyoshima H, Kozutsumi H, Maru Y; et al. (1993). "Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5404–8. PMID 7685902.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Richard I, Broux O, Chiannilkulchai N; et al. (1995). "Regional localization of human chromosome 15 loci". Genomics. 23 (3): 619–27. PMID 7851890.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kozutsumi H, Toyoshima H, Hagiwara K; et al. (1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID 8084603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kozutsumi H, Toyoshima H, Hagiwara K; et al. (1993). "Identification of the human ltk gene product in placenta and hematopoietic cell lines". Biochem. Biophys. Res. Commun. 190 (2): 674–9. doi:10.1006/bbrc.1993.1101. PMID 8427607.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueno H, Sasaki K, Kozutsumi H; et al. (1996). "Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase". J. Biol. Chem. 271 (44): 27707–14. PMID 8910363.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Snijders AJ, Ho SC, Haase VH; et al. (1997). "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin". J. Biol. Chem. 272 (2): 1297–301. PMID 8995435.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueno H, Honda H, Nakamoto T; et al. (1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Espanel X, Huguenin-Reggiani M, Van Huijsduijnen RH (2003). "The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities". Protein Sci. 11 (10): 2326–34. PMID 12237455.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li N, Nakamura K, Jiang Y; et al. (2004). "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus". Hum. Mol. Genet. 13 (2): 171–9. doi:10.1093/hmg/ddh020. PMID 14695357.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)