LOXL2

Lysyl oxidase-like 2
Identifiers
Symbols	LOXL2 ; LOR2; WS9-14
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1742
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LOXL2 202998 s at tn.png
File:PBB GE LOXL2 202997 s at tn.png
File:PBB GE LOXL2 202999 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Lysyl oxidase-like 2, also known as LOXL2, is a human gene.

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Further reading

• Csiszar K (2001). "Lysyl oxidases: a novel multifunctional amine oxidase family". Prog. Nucleic Acid Res. Mol. Biol. 70: 1–32. PMID 11642359.
• Molnar J, Fong KS, He QP; et al. (2003). "Structural and functional diversity of lysyl oxidase and the LOX-like proteins". Biochim. Biophys. Acta. 1647 (1–2): 220–4. PMID 12686136.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Saito H, Papaconstantinou J, Sato H, Goldstein S (1997). "Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence". J. Biol. Chem. 272 (13): 8157–60. PMID 9079631.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jourdan-Le Saux C, Le Saux O, Donlon T; et al. (1998). "The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3". Genomics. 51 (2): 305–7. doi:10.1006/geno.1998.5356. PMID 9722957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jourdan-Le Saux C, Tronecker H, Bogic L; et al. (1999). "The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues". J. Biol. Chem. 274 (18): 12939–44. PMID 10212285.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hein S, Yamamoto SY, Okazaki K; et al. (2001). "Lysyl oxidases: expression in the fetal membranes and placenta". Placenta. 22 (1): 49–57. doi:10.1053/plac.2000.0580. PMID 11162352.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akiri G, Sabo E, Dafni H; et al. (2003). "Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo". Cancer Res. 63 (7): 1657–66. PMID 12670920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rost T, Pyritz V, Rathcke IO; et al. (2003). "Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas". Anticancer Res. 23 (2B): 1565–73. PMID 12820424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vadasz Z, Kessler O, Akiri G; et al. (2005). "Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2". J. Hepatol. 43 (3): 499–507. doi:10.1016/j.jhep.2005.02.052. PMID 16023247.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D; et al. (2006). "A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression". EMBO J. 24 (19): 3446–58. doi:10.1038/sj.emboj.7600781. PMID 16096638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akagawa H, Narita A, Yamada H; et al. (2007). "Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms". Hum. Genet. 121 (3–4): 377–87. doi:10.1007/s00439-007-0333-3. PMID 17287949.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)