HMGN1

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High-mobility group nucleosome binding domain 1
Identifiers
Symbols HMGN1 ; FLJ27265; FLJ31471; HMG14; MGC104230; MGC117425
External IDs Template:OMIM5 Template:MGI HomoloGene: 3643
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

High-mobility group nucleosome binding domain 1, also known as HMGN1, is a human gene.[1]

Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM][1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1".

Further reading

  • Pash J, Popescu N, Matocha M; et al. (1990). "Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16". Proc. Natl. Acad. Sci. U.S.A. 87 (10): 3836–40. PMID 2140193.
  • Landsman D, McBride OW, Soares N; et al. (1989). "Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family". J. Biol. Chem. 264 (6): 3421–7. PMID 2563381.
  • Landsman D, Srikantha T, Westermann R, Bustin M (1987). "Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family". J. Biol. Chem. 261 (34): 16082–6. PMID 3782107.
  • Leffak M, Trempe JP (1985). "Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus". Nucleic Acids Res. 13 (13): 4853–69. PMID 4022776.
  • Postnikov YV, Trieschmann L, Rickers A, Bustin M (1995). "Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores". J. Mol. Biol. 252 (4): 423–32. doi:10.1006/jmbi.1995.0508. PMID 7563062.
  • Ding HF, Rimsky S, Batson SC; et al. (1994). "Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14". Science. 265 (5173): 796–9. PMID 8047885.
  • Pash JM, Alfonso PJ, Bustin M (1993). "Aberrant expression of high mobility group chromosomal protein 14 affects cellular differentiation". J. Biol. Chem. 268 (18): 13632–8. PMID 8514795.
  • Bustin M, Alfonso PJ, Pash JM; et al. (1996). "Characterization of transgenic mice with an increased content of chromosomal protein HMG-14 in their chromatin". DNA Cell Biol. 14 (12): 997–1005. PMID 8534374.
  • Hock R, Scheer U, Bustin M (1999). "Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport". J. Cell Biol. 143 (6): 1427–36. PMID 9852141.
  • Louie DF, Gloor KK, Galasinski SC; et al. (2000). "Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry". Protein Sci. 9 (1): 170–9. PMID 10739259.
  • Bergel M, Herrera JE, Thatcher BJ; et al. (2000). "Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes". J. Biol. Chem. 275 (15): 11514–20. PMID 10753971.
  • Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
  • Prymakowska-Bosak M, Misteli T, Herrera JE; et al. (2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin". Mol. Cell. Biol. 21 (15): 5169–78. doi:10.1128/MCB.21.15.5169-5178.2001. PMID 11438671.
  • Prymakowska-Bosak M, Hock R, Catez F; et al. (2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins". Mol. Cell. Biol. 22 (19): 6809–19. PMID 12215538.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Soloaga A, Thomson S, Wiggin GR; et al. (2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". EMBO J. 22 (11): 2788–97. doi:10.1093/emboj/cdg273. PMID 12773393.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zou Y, Jiang X, Wang Y (2004). "Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells". Biochemistry. 43 (20): 6322–9. doi:10.1021/bi0362828. PMID 15147216.
  • Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

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