FGFR1OP

FGFR1 oncogene partner
PDB rendering based on 2d68.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2d68​
Identifiers
Symbols	FGFR1OP ; FOP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5116
Gene ontology Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

FGFR1 oncogene partner, also known as FGFR1OP, is a human gene.

This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.

Further reading

• Reither A, Hehlmann R, Goldman JM, Cross NC (1999). "[The 8p11 myeloproliferative syndrome]". Med. Klin. (Munich). 94 (4): 207–10. PMID 10373756.CS1 maint: Multiple names: authors list (link)
• Popovici C, Zhang B, Grégoire MJ; et al. (1999). "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Blood. 93 (4): 1381–9. PMID 9949182.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guasch G, Ollendorff V, Borg JP; et al. (2001). "8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways". Mol. Cell. Biol. 21 (23): 8129–42. doi:10.1128/MCB.21.23.8129-8142.2001. PMID 11689702.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guasch G, Delaval B, Arnoulet C; et al. (2004). "FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice". Blood. 103 (1): 309–12. doi:10.1182/blood-2003-05-1690. PMID 12969958.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Wilkinson CJ, Mayor T; et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brill LM, Salomon AR, Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan X, Habedanck R, Nigg EA (2006). "A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring". Mol. Biol. Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMID 16314388.CS1 maint: Multiple names: authors list (link)
• Mikolajka A, Yan X, Popowicz GM; et al. (2006). "Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization". J. Mol. Biol. 359 (4): 863–75. doi:10.1016/j.jmb.2006.03.070. PMID 16690081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mano Y, Takahashi K, Ishikawa N; et al. (2007). "Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer". Cancer Sci. 98 (12): 1902–13. doi:10.1111/j.1349-7006.2007.00610.x. PMID 17888034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)