CSRP3

Cysteine and glycine-rich protein 3 (cardiac LIM protein)
Identifiers
Symbols	CSRP3 ; CLP; CRP3; MLP; CMD1M; LMO4; MGC14488; MGC61993
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20742
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cysteine and glycine-rich protein 3 (cardiac LIM protein), also known as CSRP3, is a human gene.

This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans.

Further reading

• Fung YW, Wang RX, Heng HH, Liew CC (1996). "Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization". Genomics. 28 (3): 602–3. doi:10.1006/geno.1995.1200. PMID 7490106.CS1 maint: Multiple names: authors list (link)
• Weiskirchen R, Pino JD, Macalma T; et al. (1996). "The cysteine-rich protein family of highly related LIM domain proteins". J. Biol. Chem. 270 (48): 28946–54. PMID 7499425.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arber S, Halder G, Caroni P (1994). "Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation". Cell. 79 (2): 221–31. PMID 7954791.CS1 maint: Multiple names: authors list (link)
• Fung YW, Wang R, Liew CC (1996). "Characterization of a human cardiac gene which encodes for a LIM domain protein and is developmentally expressed in myocardial development". J. Mol. Cell. Cardiol. 28 (6): 1203–10. doi:10.1006/jmcc.1996.0111. PMID 8782062.CS1 maint: Multiple names: authors list (link)
• Kong Y, Flick MJ, Kudla AJ, Konieczny SF (1997). "Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD". Mol. Cell. Biol. 17 (8): 4750–60. PMID 9234731.CS1 maint: Multiple names: authors list (link)
• Flick MJ, Konieczny SF (2000). "The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin". J. Cell. Sci. 113 ( Pt 9): 1553–64. PMID 10751147.
• Ecarnot-Laubriet A, De Luca K, Vandroux D; et al. (2001). "Downregulation and nuclear relocation of MLP during the progression of right ventricular hypertrophy induced by chronic pressure overload". J. Mol. Cell. Cardiol. 32 (12): 2385–95. doi:10.1006/jmcc.2000.1269. PMID 11113014.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Flick MJ, Konieczny SF (2002). "Identification of putative mammalian D-lactate dehydrogenase enzymes". Biochem. Biophys. Res. Commun. 295 (4): 910–6. PMID 12127981.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knöll R, Hoshijima M, Hoffman HM; et al. (2003). "The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy". Cell. 111 (7): 943–55. PMID 12507422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Geier C, Perrot A, Ozcelik C; et al. (2003). "Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy". Circulation. 107 (10): 1390–5. PMID 12642359.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Manetopoulos C, Hansson A, Karlsson J; et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1". Biochem. Biophys. Res. Commun. 307 (4): 891–9. PMID 12878195.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kostek MC, Chen YW, Cuthbertson DJ; et al. (2007). "Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32". Physiol. Genomics. 31 (1): 42–52. doi:10.1152/physiolgenomics.00151.2006. PMID 17519359.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)