ANGPT2

Angiopoietin 2
PDB rendering based on 1z3s.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1z3s​, 1z3u​, 2gy7​
Identifiers
Symbols	ANGPT2 ; AGPT2; ANG2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22401
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Angiopoietin 2, also known as ANGPT2, is a human gene.

Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1

See also

• Angiopoietin

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Maisonpierre PC, Suri C, Jones PF; et al. (1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. PMID 9204896.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheung AH, Stewart RJ, Marsden PA (1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics. 48 (3): 389–91. doi:10.1006/geno.1997.5207. PMID 9545648.CS1 maint: Multiple names: authors list (link)
• Sato A, Iwama A, Takakura N; et al. (1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. 10 (8): 1217–27. PMID 9723709.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Mori M, Sakamoto Y; et al. (1999). "Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma". J. Clin. Invest. 103 (3): 341–5. PMID 9927494.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valenzuela DM, Griffiths JA, Rojas J; et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. PMID 10051567.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grosios K, Leek JP, Markham AF; et al. (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet. 84 (1–2): 118–20. PMID 10343124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Procopio WN, Pelavin PI, Lee WM, Yeilding NM (1999). "Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity". J. Biol. Chem. 274 (42): 30196–201. PMID 10514510.CS1 maint: Multiple names: authors list (link)
• Kim I, Kim JH, Ryu YS; et al. (2000). "Characterization and expression of a novel alternatively spliced human angiopoietin-2". J. Biol. Chem. 275 (24): 18550–6. doi:10.1074/jbc.M910084199. PMID 10766762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mezquita J, Mezquita P, Montserrat P; et al. (2000). "Genomic structure and alternative splicing of chicken angiopoietin-2". Biochem. Biophys. Res. Commun. 275 (2): 643–51. doi:10.1006/bbrc.2000.3345. PMID 10964717.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu Y, Yu Q (2001). "Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region". J. Biol. Chem. 276 (37): 34990–8. doi:10.1074/jbc.M103661200. PMID 11447223.
• Acker T, Beck H, Plate KH (2002). "Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization". Mech. Dev. 108 (1–2): 45–57. PMID 11578860.CS1 maint: Multiple names: authors list (link)
• Ward EG, Grosios K, Markham AF, Jones PF (2002). "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3–4): 147–54. PMID 11856872.CS1 maint: Multiple names: authors list (link)
• Huang YQ, Li JJ, Hu L; et al. (2002). "Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells". Blood. 99 (5): 1646–50. PMID 11861279.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hata K, Udagawa J, Fujiwaki R; et al. (2002). "Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer". Oncology. 62 (4): 340–8. PMID 12138242.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin S, Shyu KG, Lee CC; et al. (2002). "Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells". Biochem. Biophys. Res. Commun. 296 (3): 710–5. PMID 12176040.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Geva E, Ginzinger DG, Zaloudek CJ; et al. (2002). "Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2". J. Clin. Endocrinol. Metab. 87 (9): 4213–24. PMID 12213874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paradis V, Bièche I, Dargère D; et al. (2003). "A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia". Gastroenterology. 124 (3): 651–9. doi:10.1053/gast.2003.50104. PMID 12612904.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.