ADH4

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Alcohol dehydrogenase 4 (class II), pi polypeptide
Identifiers
Symbols ADH4 ; ADH-2
External IDs Template:OMIM5 Template:MGI HomoloGene: 20162
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Alcohol dehydrogenase 4 (class II), pi polypeptide, also known as ADH4, is a human gene.[1]

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide".

Further reading

  • Jörnvall H (1994). "The alcohol dehydrogenase system". EXS. 71: 221–9. PMID 8032153.
  • Edman K, Maret W (1993). "Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classes". Hum. Genet. 90 (4): 395–401. PMID 1362387.
  • von Bahr-Lindström H, Jörnvall H, Höög JO (1991). "Cloning and characterization of the human ADH4 gene". Gene. 103 (2): 269–74. PMID 1889753.
  • Höög JO, von Bahr-Lindström H, Hedén LO; et al. (1987). "Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit". Biochemistry. 26 (7): 1926–32. PMID 3036213.
  • Mårdh G, Dingley AL, Auld DS, Vallee BL (1987). "Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 8908–12. PMID 3466164.
  • Li M, Edenberg HJ (1998). "Function of cis-acting elements in human alcohol dehydrogenase 4 (ADH4) promoter and role of C/EBP proteins in gene expression". DNA Cell Biol. 17 (4): 387–97. PMID 9570155.
  • Tryggvason K, Romert A, Eriksson U (2001). "Biosynthesis of 9-cis-retinoic acid in vivo. The roles of different retinol dehydrogenases and a structure-activity analysis of microsomal retinol dehydrogenases". J. Biol. Chem. 276 (22): 19253–8. doi:10.1074/jbc.M100215200. PMID 11279029.
  • Xu XR, Huang J, Xu ZG; et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456.
  • Iida A, Saito S, Sekine A; et al. (2002). "Thirteen single-nucleotide polymorphisms (SNPs) in the alcohol dehydrogenase 4 (ADH4) gene locus". J. Hum. Genet. 47 (2): 74–6. PMID 11916005.
  • Strömberg P, Svensson S, Hedberg JJ; et al. (2002). "Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2". Cell. Mol. Life Sci. 59 (3): 552–9. PMID 11964133.
  • Chou CF, Lai CL, Chang YC; et al. (2002). "Kinetic mechanism of human class IV alcohol dehydrogenase functioning as retinol dehydrogenase". J. Biol. Chem. 277 (28): 25209–16. doi:10.1074/jbc.M201947200. PMID 11997393.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Galter D, Carmine A, Buervenich S; et al. (2003). "Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain". Eur. J. Biochem. 270 (6): 1316–26. PMID 12631290.
  • Neumark YD, Friedlander Y, Durst R; et al. (2004). "Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population". Alcohol. Clin. Exp. Res. 28 (1): 10–4. doi:10.1097/01.ALC.0000108667.79219.4D. PMID 14745297.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Luo X, Kranzler HR, Zuo L; et al. (2006). "ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies". Pharmacogenet. Genomics. 15 (11): 755–68. PMID 16220108.
  • Luo X, Kranzler HR, Zuo L; et al. (2006). "ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies". Neuropsychopharmacology. 31 (5): 1085–95. doi:10.1038/sj.npp.1300925. PMID 16237392.
  • Luo X, Kranzler HR, Zuo L; et al. (2007). "Personality traits of agreeableness and extraversion are associated with ADH4 variation". Biol. Psychiatry. 61 (5): 599–608. doi:10.1016/j.biopsych.2006.05.017. PMID 17069770.

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