ABCB9
| ATP-binding cassette, sub-family B (MDR/TAP), member 9 | |||||||||||
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| Symbols | ABCB9 ; EST122234; KIAA1520; TAPL | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 10491 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
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ATP-binding cassette, sub-family B (MDR/TAP), member 9, also known as ABCB9, is a human gene.[1]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specifications.[1]
See also
References
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum. Mol. Genet. 5 (10): 1649–55. PMID 8894702.
- Zhang F, Zhang W, Liu L; et al. (2000). "Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes". J. Biol. Chem. 275 (30): 23287–94. doi:10.1074/jbc.M001819200. PMID 10748049.
- Nagase T, Kikuno R, Ishikawa K; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. PMID 10819331.
- Kobayashi A, Kasano M, Maeda T; et al. (2000). "A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2". J. Biochem. 128 (4): 711–8. PMID 11011155.
- Saito S, Iida A, Sekine A; et al. (2002). "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population". J. Hum. Genet. 47 (1): 38–50. PMID 11829140.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Kobayashi A, Hori S, Suita N, Maeda M (2003). "Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity". Biochem. Biophys. Res. Commun. 309 (4): 815–22. PMID 13679046.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Homma K, Kikuno RF, Nagase T; et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain". J. Mol. Biol. 343 (5): 1207–20. doi:10.1016/j.jmb.2004.09.028. PMID 15491607.
- Wolters JC, Abele R, Tampé R (2005). "Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)". J. Biol. Chem. 280 (25): 23631–6. doi:10.1074/jbc.M503231200. PMID 15863492.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Ohashi-Kobayashi A, Ohashi K, Du WB; et al. (2006). "Examination of drug resistance activity of human TAP-like (ABCB9) expressed in yeast". Biochem. Biophys. Res. Commun. 343 (2): 597–601. doi:10.1016/j.bbrc.2006.03.002. PMID 16554024.
External links
- ABCB9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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