Neurofibrillary tangle

Revision as of 14:16, 20 August 2012 by WikiBot (talk | contribs) (Robot: Automated text replacement (-{{SIB}} +, -{{EH}} +, -{{EJ}} +, -{{Editor Help}} +, -{{Editor Join}} +))
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
Neurofibrillary tangle

WikiDoc Resources for Neurofibrillary tangle

Articles

Most recent articles on Neurofibrillary tangle

Most cited articles on Neurofibrillary tangle

Review articles on Neurofibrillary tangle

Articles on Neurofibrillary tangle in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Neurofibrillary tangle

Images of Neurofibrillary tangle

Photos of Neurofibrillary tangle

Podcasts & MP3s on Neurofibrillary tangle

Videos on Neurofibrillary tangle

Evidence Based Medicine

Cochrane Collaboration on Neurofibrillary tangle

Bandolier on Neurofibrillary tangle

TRIP on Neurofibrillary tangle

Clinical Trials

Ongoing Trials on Neurofibrillary tangle at Clinical Trials.gov

Trial results on Neurofibrillary tangle

Clinical Trials on Neurofibrillary tangle at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Neurofibrillary tangle

NICE Guidance on Neurofibrillary tangle

NHS PRODIGY Guidance

FDA on Neurofibrillary tangle

CDC on Neurofibrillary tangle

Books

Books on Neurofibrillary tangle

News

Neurofibrillary tangle in the news

Be alerted to news on Neurofibrillary tangle

News trends on Neurofibrillary tangle

Commentary

Blogs on Neurofibrillary tangle

Definitions

Definitions of Neurofibrillary tangle

Patient Resources / Community

Patient resources on Neurofibrillary tangle

Discussion groups on Neurofibrillary tangle

Patient Handouts on Neurofibrillary tangle

Directions to Hospitals Treating Neurofibrillary tangle

Risk calculators and risk factors for Neurofibrillary tangle

Healthcare Provider Resources

Symptoms of Neurofibrillary tangle

Causes & Risk Factors for Neurofibrillary tangle

Diagnostic studies for Neurofibrillary tangle

Treatment of Neurofibrillary tangle

Continuing Medical Education (CME)

CME Programs on Neurofibrillary tangle

International

Neurofibrillary tangle en Espanol

Neurofibrillary tangle en Francais

Business

Neurofibrillary tangle in the Marketplace

Patents on Neurofibrillary tangle

Experimental / Informatics

List of terms related to Neurofibrillary tangle

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Neurofibrillary tangles were first described by Alois Alzheimer in one of his patients suffering from the disorder now referred to as Alzheimer's disease.

Pathophysiology

Neurofibrillary tangles are pathological protein aggregates found within neurons in cases of Alzheimer's disease. Tangles are formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form. (These aggregations of hyperphosphorylated tau protein are also referred to as PHF, or "Paired Helical Filaments"). The precise mechanism of tangle formation is not completely understood, and it is still controversial whether tangles are a primary causative factor in the disease or play a more peripheral role.

It is also believed that neurofibrillary tangles are seen in Creutzfeldt-Jakob disease. Neurofibrillary tangles are also found in Supranuclear Palsy.

See Also


Template:Skin and subcutaneous tissue symptoms and signs Template:Nervous and musculoskeletal system symptoms and signs Template:Urinary system symptoms and signs Template:Cognition, perception, emotional state and behaviour symptoms and signs Template:Speech and voice symptoms and signs Template:General symptoms and signs


Template:WikiDoc Sources