Heparin-induced thrombocytopenia causes

Heparin-induced thrombocytopenia
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Aric C. Hall, M.D., [3]

Overview

Heparin-induced thrombocytopenia is diagnosed when the platelet count falls by > 50% typically after 5-10 days of heparin therapy. The causes of the condition depends on type of heparin (unfractionated heparin > low molecular weight heparin), duration of therapy, females and type of patients (commoner in surgical patients that require large amount of heparin)

Causes

• Duration of heparin treatment; long duration, up to 2 weeks is associated with the greatest risk.
• The type of heparin involved; unfractionated heparinUFH has a greater risk than low molecular weight heparin LMWH.
• The type of patient; surgical patients are at higher risk than medical; cardiac surgical patients have the highest risk of all.
• Females have a higher risk.