Seminoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Seminoma grows slower than non-seminomatous germ cell tumors. Common complications of seminoma include recurrence, lymph node metastasis, distant metastasis, and secondary malignancies. Prognosis of seminoma is good for all stages with greater than 90% cure rate. The International Germ Cell Cancer Consensus Group divides seminoma into two prognosis groups: good and intermediate.

Natural History

Seminoma grows slower than non-seminomatous germ cell tumors.

Complications

Common complications of seminoma include:

• Recurrence
• Lymph node metastasis
• Distant metastasis
• Increased risk of seminoma in the remaining testicle
• Increased risk of other cancers (second malignancies)

• Mesothelioma and cancer of the lung
• Colon cancer
• Bladder cancer
• Pancreatic cancer
• Stomach cancer

Prognosis

• Prognosis for stage I is excellent, and the survival rate of patients with seminoma for satgr I is approximately 100%.
• Prognosis for stage II is generally good, the 5-year mortality survival rate of patients with satge II of seminoma is approximately 97%.
• Prognosis for stage III is generally good, the 5-year mortality survival rate of patients with satge II of seminoma is approximately 85%