Splenic marginal zone lymphoma medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

The predominant therapy for splenic marginal zone lymphoma is surgery. Adjunctive radiotherapy, chemotherapy, and biological therapy may be required. The optimal therapy for splenic marginal zone lymphoma depends on the clinical presentation.


Medical Therapy

Watchful waiting

  • It is a slow growing tumor so patients may not need treatment right away unless symptomatic. Asymptomatic patients may be observed every 3-6 months.[1]

Immunotherapy

Chemotherapy

Immunochemotherapy

Antiviral therapy

References

  1. Matutes E, Oscier D, Montalban C, Berger F, Callet-Bauchu E, Dogan A, Felman P, Franco V, Iannitto E, Mollejo M, Papadaki T, Remstein ED, Salar A, Solé F, Stamatopoulos K, Thieblemont C, Traverse-Glehen A, Wotherspoon A, Coiffier B, Piris MA (March 2008). "Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria". Leukemia. 22 (3): 487–95. doi:10.1038/sj.leu.2405068. PMID 18094718.
  2. 2.0 2.1 Tsimberidou AM, Catovsky D, Schlette E, O'Brien S, Wierda WG, Kantarjian H, Garcia-Manero G, Wen S, Do KA, Lerner S, Keating MJ (July 2006). "Outcomes in patients with splenic marginal zone lymphoma and marginal zone lymphoma treated with rituximab with or without chemotherapy or chemotherapy alone". Cancer. 107 (1): 125–35. doi:10.1002/cncr.21931. PMID 16700034.
  3. Bennett M, Schechter GP (April 2010). "Treatment of splenic marginal zone lymphoma: splenectomy versus rituximab". Semin. Hematol. 47 (2): 143–7. doi:10.1053/j.seminhematol.2010.01.004. PMID 20350661.
  4. Kalpadakis C, Pangalis GA, Angelopoulou MK, Sachanas S, Kontopidou FN, Yiakoumis X, Kokoris SI, Dimitriadou EM, Dimopoulou MN, Moschogiannis M, Korkolopoulou P, Kyrtsonis MC, Siakantaris MP, Papadaki T, Tsaftaridis P, Plata E, Papadaki HE, Vassilakopoulos TP (2013). "Treatment of splenic marginal zone lymphoma with rituximab monotherapy: progress report and comparison with splenectomy". Oncologist. 18 (2): 190–7. doi:10.1634/theoncologist.2012-0251. PMC 3579603. PMID 23345547.
  5. Perrone S, D'Elia GM, Annechini G, Ferretti A, Tosti ME, Foà R, Pulsoni A (May 2016). "Splenic marginal zone lymphoma: Prognostic factors, role of watch and wait policy, and other therapeutic approaches in the rituximab era". Leuk. Res. 44: 53–60. doi:10.1016/j.leukres.2016.03.005. PMID 27030961.
  6. Olszewski AJ, Ali S (March 2014). "Comparative outcomes of rituximab-based systemic therapy and splenectomy in splenic marginal zone lymphoma". Ann. Hematol. 93 (3): 449–58. doi:10.1007/s00277-013-1900-4. PMID 24057925.
  7. 7.0 7.1 Else M, Marín-Niebla A, de la Cruz F, Batty P, Ríos E, Dearden CE, Catovsky D, Matutes E (November 2012). "Rituximab, used alone or in combination, is superior to other treatment modalities in splenic marginal zone lymphoma". Br. J. Haematol. 159 (3): 322–8. doi:10.1111/bjh.12036. PMID 23016878.
  8. Troussard X, Valensi F, Duchayne E, Garand R, Felman P, Tulliez M, Henry-Amar M, Bryon PA, Flandrin G (June 1996). "Splenic lymphoma with villous lymphocytes: clinical presentation, biology and prognostic factors in a series of 100 patients. Groupe Francais d'Hématologie Cellulaire (GFHC)". Br. J. Haematol. 93 (3): 731–6. PMID 8652403.
  9. Bolam S, Orchard J, Oscier D (October 1997). "Fludarabine is effective in the treatment of splenic lymphoma with villous lymphocytes". Br. J. Haematol. 99 (1): 158–61. PMID 9359516.
  10. Cervetti G, Galimberti S, Pelosini M, Ghio F, Cecconi N, Petrini M (September 2013). "Significant efficacy of 2-chlorodeoxyadenosine{+/-} rituximab in the treatment of splenic marginal zone lymphoma (SMZL): extended follow-up". Ann. Oncol. 24 (9): 2434–8. doi:10.1093/annonc/mdt181. PMID 23712547.
  11. Arcaini L, Vallisa D, Rattotti S, Ferretti VV, Ferreri AJ, Bernuzzi P, Merli M, Varettoni M, Chiappella A, Ambrosetti A, Tucci A, Rusconi C, Visco C, Spina M, Cabras G, Luminari S, Tucci M, Musto P, Ladetto M, Merli F, Stelitano C, d'Arco A, Rigacci L, Levis A, Rossi D, Spedini P, Mancuso S, Marino D, Bruno R, Baldini L, Pulsoni A (July 2014). "Antiviral treatment in patients with indolent B-cell lymphomas associated with HCV infection: a study of the Fondazione Italiana Linfomi". Ann. Oncol. 25 (7): 1404–10. doi:10.1093/annonc/mdu166. PMID 24799461.
  12. Rossotti R, Travi G, Pazzi A, Baiguera C, Morra E, Puoti M (January 2015). "Rapid clearance of HCV-related splenic marginal zone lymphoma under an interferon-free, NS3/NS4A inhibitor-based treatment. A case report". J. Hepatol. 62 (1): 234–7. doi:10.1016/j.jhep.2014.09.031. PMID 25285757.

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