Hereditary spherocytosis surgery

Hereditary spherocytosis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Hereditary spherocytosis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Hereditary spherocytosis surgery On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Hereditary spherocytosis surgery All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Hereditary spherocytosis surgery
CDC on Hereditary spherocytosis surgery
Hereditary spherocytosis surgery in the news
Blogs on Hereditary spherocytosis surgery
Directions to Hospitals Treating Hereditary spherocytosis
Risk calculators and risk factors for Hereditary spherocytosis surgery

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.

Surgery

• Splenectomy is the definitive treatment for HS. ^[3] Except in the unusual autosomal recessive variant of HS, splenectomy usually eliminates hemolysis and the associated signs and symptoms. ^[4] Interestinagly, splenectomy does little to correct the cytoskeletal membrane defects of HS; an atomic force microscopy study by Li et al found that after splenectomy, erythrocytes were larger but still spheroidal-shaped, with a disorganized membrane ultrastructure and reduced surface particle size.