Hemolytic-uremic syndrome overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In medicine, hemolytic-uremic syndrome (or haemolytic-uraemic syndrome, abbreviated HUS) is a disease characterized by microangiopathic hemolytic anemia, acute renal failure and a low platelet count (thrombocytopenia). It is due to the abnormal blood clotting with in the capillaries leading to RBC shearing and destruction while passing through clogged capillaries and obstruction of kidney filtration system by damaged RBC's lead to acute kidney injury and is one of the leading causes of Acute Renal failure in children. The two main types are Typical and atypical Hemolytic uremic syndrome(HUS). Typical HUS is caused following a diarrheal infection by E.Coli OH157:H7 and is responsible for 90 percent of HUS cases in Children. Atypical HUS is not associated with gastrointestinal symptoms and also has a less favorable outcome.