Glanzmann's thrombasthenia natural history, complications and prognosis
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Glanzmann's thrombasthenia |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Common complications of include sever fatal bleeding following major surgeries , labor and delivery.
84% of patients with Glanzmann’s thrombasthenia require at least once in their life red blood cell transfusion.
the episodes of severe spontaneous hemorrhage is reduced with age.
The of the bleeding episodes in can vary greatly among affected individuals, even in the same family.
Patients with Glanzmann thrombasthenia, even the individuals of the same family and ethnicity manifest diverse bleeding frequency tendency and severity and even within the same family or ethnic group
In patients with Glanzmann’s thrombasthenia, the quality of life of is influenced by several mucocutaneous hemorrhages and heavy bleeding in various conditions such as menstruation,trauma and surgery .
A considerable complication of Glanzmann’s thrombasthenia is iron deficiency anemia.
Prognosis is generally excellent with good supportive care and the mortality rate of patients with Glanzmann’s thrombasthenia is relatively low. [1] [2]
Natural History, Complications and Prognosis
- Common complications of include sever fatal bleeding following major surgeries , labor and delivery.
- 84% of patients with Glanzmann’s thrombasthenia require at least once in their life red blood cell transfusion.
- the episodes of severe spontaneous hemorrhage is reduced with age.
- The of the bleeding episodes in can vary greatly among affected individuals, even in the same family.
- Patients with Glanzmann thrombasthenia, even the individuals of the same family and ethnicity manifest diverse bleeding frequency tendency and severity and even within the same family or ethnic group
- In patients with Glanzmann’s thrombasthenia, the quality of life of is influenced by several mucocutaneous hemorrhages and heavy bleeding in various conditions such as menstruation,trauma and surgery .
- A considerable complication of Glanzmann’s thrombasthenia is iron deficiency anemia.
- Prognosis is generally excellent with good supportive care and the mortality rate of patients with Glanzmann’s thrombasthenia is relatively low.[1]
References
- ↑ Jump up to: 1.0 1.1 Solh T, Botsford A, Solh M (2015). "Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options". J Blood Med. 6: 219–27. doi:10.2147/JBM.S71319. PMC 4501245. PMID 26185478.
- ↑ Fiore M, Nurden AT, Nurden P, Seligsohn U (2012). "Clinical utility gene card for: Glanzmann thrombasthenia". Eur J Hum Genet. 20 (10). doi:10.1038/ejhg.2012.151. PMC 3449071. PMID 22781097.