Post-streptococcal glomerulonephritis medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

Medical therapy

The mainstay of treatment is pharmacotherapy, however dietary therapy is useful for controlling edema and hypertension

Dietary therapy

  • Low salt intake
  • Low protein intake
  • Water restrictions

Pharmacotherapy

  • If streptococcal infection is still present, it should be treated with antibiotics[1]
  • To control severe hypertension, following drugs can be used:
    • Preferred regimen: Labetalol 0.5-2 mg/kg/h IV
    • If refractory to labetalol then, Preferred regimen: Diazoxide or Nitroprusside 0.5-2 mcg/kg/min IV
  • For mild to moderate hypertension:
    • Preferred regimen: Furosemide 1-3 mg/kg PO q24h

References

  1. Zoch-Zwierz W, Wasilewska A, Biernacka A, Tomaszewska B, Winiecka W, Wierciński R, Porowski T (2001). "[The course of post-streptococcal glomerulonephritis depending on methods of treatment for the preceding respiratory tract infection]". Wiad. Lek. (in Polish). 54 (1–2): 56–63. PMID 11344703.

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