The exact function of KIAA0644 is not known. It is, however, a member of the leucine-rich repeat family of proteins, which are known to be involved in protein-protein interactions. This protein is known to interact with the TLR4 protein.
TRIL is a component of the TLR4 complex and is induced in a number of cell types by lipopolysaccharide (LPS).[2]
Protein sequence
The main isoform of the human protein is 811 amino long and is composed primarily of leucine (17%), alanine and arginine (~10%), and glycine (~ 8.5%) residues. The protein sequence is predicted to consists mostly of α-helices and a few β-sheet
Homology
KIAA0644 is conserved well among mammals but can be found in all chordates with lower sequence identities.
Gene neighborhood
The KIAA0644 gene is neighbors to mRNA-cAMP responsive element binding gene downstream and mRNA carboxypeptidase and serine carboxypeptidase gene upstream [3][4]
↑Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA (September 2009). "TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain". J. Immunol. 183 (6): 3989–95. doi:10.4049/jimmunol.0901518. PMID19710467.
↑Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID9734811.
