Peutz-Jeghers syndrome secondary prevention
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Secondary prevention strategies to detect intestinal and extraintestinal malignancies in Peutz-Jeghers syndrome include enteroscopy and colonoscopy.[1]
Secondary Prevention
At time of diagnosis, screening for cancerous lesions among patients with Peutz-Jeghers syndrome include the following:[2][3]
- Enteroscopy
- Colonoscopy (every 2 years)
- Small intestine radiography (every 2 years)
- Esophagogastroduodenoscopy (every 2 years)
- Pancreatic ultrasound (annually)
- Endoscopic ultrasound
- Magnetic resonance cholangiopancreatography (MRCP)
- Abdominal CT
- Pelvic ultrasound (annually)
- Testicular ultrasound (annually)
- Mammography at ages 25, 30, 35, and 38 years, then every 2 years until age 50 years, then annually
- Cervical Papanicolaou test (Pap test) (annually).
- Physical examination that includes evaluation of the breasts, abdomen, pelvis, and testes should be performed by a physician (annually)
- Complete blood count (CBC) to check for anemia should be done (annually)
References
- ↑ Peutz-Jeghers syndrome https://online.epocrates.com/u/29441128/Peutz-Jeghers+syndrome
- ↑ Boardman LA, Thibodeau SN, Schaid DJ; et al. (1998). "Increased risk for cancer in patients with the Peutz-Jeghers syndrome". Ann. Intern. Med. 128 (11): 896–9. PMID 9634427.
- ↑ Peutz-Jeghers syndrome https://www.nlm.nih.gov/medlineplus/ency/article/000244.htm