Adrenocortical carcinoma staging
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Differentiating Adrenocortical carcinoma from other Diseases |
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Adrenocortical carcinoma staging On the Web |
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Risk calculators and risk factors for Adrenocortical carcinoma staging |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
According to the TNM staging system, there are four stages of adrenocortical cancer based on the tumor size, lymph nodes, and distant metastasis. Each stage is assigned a number and letter that designates the number of lymph nodes involved and presence/absence of distant metastasis.
Staging of adrenocortical carcinoma
The AJCC has designated staging by TNM to define adrenocortical carcinoma
Staging according to TNM staging system
Stage | T | N | M |
I | T1 | N0 | M0 |
II | T2 | N0 | M0 |
III | T1 | N1 | M0 |
T2 | N1 | M0 | |
T3 | N0 | M0 | |
IV | T3 | N1 | M0 |
T4 | N0 | M0 | |
T4 | N1 | M0 | |
Any T | Any N | M1 |
Tumor size (T)
TX | Primary tumor cannot be assessed |
T0 | No evidence of primary tumor |
T1 | Tumor ≤5 cm in greatest dimension, no extra-adrenal invasion |
T2 | Tumor >5 cm, no extra-adrenal invasion |
T3 | Tumor of any size with local invasion, but not invading adjacent organs |
T4 | Tumor of any size with invasion of adjacent organs |
Lymph nodes (N)
NX | Regional lymph nodes cannot be assessed |
N0 | No regional lymph node metastasis |
N1 | Metastases in regional lymph node(s) |
Metastasis (M)
M0 | No distant metastasis |
M1 | Distant metastasis |
Staging
Stage | Description |
---|---|
TX | Primary tumor cannot be assessed |
T0 | No evidence of primary tumor |
T1 | Tumor ≤2 cm in greatest dimension limited to the thyroid |
T1a | Tumor ≤1 cm, limited to the thyroid |
T1b | Tumor >1 cm but ≤2 cm in greatest dimension, limited to the thyroid |
T2 | Tumor >2 cm but ≤4 cm in greatest dimension, limited to the thyroid |
T3 | Tumor >4 cm in greatest dimension limited to the thyroid or any tumor with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues) |
T4a | Moderately advanced disease |
Tumor of any size extending beyond the thyroid capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve | |
T4b | Very advanced disease |
Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessel |
Stage | Description |
---|---|
NX | Regional lymph node cannot be assessed |
N0 | No regional lymph node metastasis]] |
N1 | Regional lymph node metastasis |
N1a | Metastases to Level VI (pretracheal, paratracheal, and prelaryngeal/Delphian lymph nodes) |
N1b | Metastases to unilateral, bilateral, or contralateral cervical (Levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (Level VII) |
Stage | Description |
---|---|
M0 | No distant metastasis |
M1 | Distant metastasis |
Stage | T | N | M |
---|---|---|---|
Papillary thyroid carcinoma | |||
YOUNGER THAN 45 YEARS | |||
I | Any T | Any N | M0 |
II | Any T | Any N | M1 |
45 YEARS AND OLDER | |||
I | T1 | Any N | M1 |
II | T2 | N0 | M0 |
III | T3 | N0 | M0 |
T1 | N1a | M0 | |
T2 | N1a | M0 | |
T3 | N1a | M0 | |
IVA | T4a | N0 | M0 |
T4a | N1a | M0 | |
T1 | N1b | M0 | |
T2 | N1b | M0 | |
T3 | N1b | M0 | |
T4a | N1b | M0 | |
IVB | T4b | Any N | M0 |
Stage IVC | Any T | Any N | M1 |