Seborrheic dermatitis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2]; Aysha Anwar, M.B.B.S[3]

Synonyms and keywords: Seborrheic eczema

Overview

Seborrhoeic eczema (also known as Seborrheic dermatitis AmE, seborrhea) is a skin disorder affecting the scalp, face, and trunk. Seborrhoeic dermatitis causes flaky, itchy, red skin and temporary hair loss. It particularly affects the sebum-gland rich areas of skin. Causes of seborrhoeic dermatitis include Malassezia furfur (formerly known as Pityrosporum ovale), as well as genetic, environmental, hormonal, and immune-system factors. Medical therapy for seborrhoeic dermatitis includes antifungal agents, corticosteroids, and lithium salts.

Historical Perspective

Classification

Pathophysiology

Complete pathogenesis of seborrheic dermatitis is not fully understood.However, studies have demonstrated strong correlation between presence of fungal yeast Malasezia and seborrheic dermatitis.[1] There are two species of Malasezia that predominantly related to

Causes

The cause of seborrhoeic dermatitis remains unknown, although many factors have been implicated. The widely present yeast, Malassezia furfur (formerly known as Pityrosporum ovale), is involved,[2][3] as well as genetic, environmental, hormonal, and immune-system factors.[4][5] A suggestion that seborrhoeic dermatitis is an inflammatory response to this yeast has yet to be proven.[6] Those afflicted with seborrhoeic dermatitis have an unfavourable epidermic response to the infection, with the skin becoming inflamed and flaking.

In children, excessive vitamin A intake can cause seborrhoeic dermatitis.[7] Lack of biotin,[8] pyridoxine (vitamin B6)[8][9] and riboflavin (vitamin B2)[8] may also be a cause.

Differentiating Seborrheic dermatitis from Other Diseases

Epidemiology and Demographics

Risk Factors

===Most common risk factors for Seborrheic dermatitis===[10][11]

  • Immunocompromised Patients such as organ transplant recepients, patients with HIV, Hep C, chronic alcohalic pancreatitis and various malignancies such as lymphoma[12]
  • Neurologic and psychiatric cases such as patients with Parkinsonism, patients with Depressive mood disorder, tardive dyskinesia,, traumatic brain injury, epilepsy, facial nerve palsy, spinal cord injury
  • Genetic disorders such as patients with Downs syndrome, Hailey Hailey disease, Cardiofaciocutaneous syndrome

Other risk factors

  • Patients treated with psoralene and ultravoilet light A for psoriasis are seen to have a predisposition for seborreic dermatitis.
  • Male population is more prone to develop seborrheic dermnatitis as compared to females

Screening

Natural History, Complications, and Prognosis

Natural History

Complications

Side effects to inflammation may include temporary hair loss. If severe outbreaks go untreated for long periods of time, permanent hair loss may result due to damaged hair follicles.

Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Head

Ear

Neck

Trunk

Extremities

Genitals

Medical Therapy

  • Seborrheic dermatitis[13]
  • 1. Antifungal agents
  • Preferred regimen (1): Ketoconazole 2% in shampoo, foam, gel, or cream
  • Scalp: Twice/week for clearance THEN once/week or every other week for maintenance
  • Other areas: From bid to twice/week for clearance THEN from twice/week to once every other week for maintenance
  • Preferred regimen (2): Bifonazole 1% in shampoo or cream
  • Scalp: 3 times/week for clearance
  • Other areas: qd for clearance
  • Preferred regimen (3): Ciclopirox olamine (also called ciclopirox) 1.0% or 1.5% in shampoo or cream
  • Scalp: Twice to 3 times/week for clearance THEN once/week or every 2 week for maintenance
  • Other areas: Twice daily for clearance THEN qd for maintenance
  • 2. Corticosteroids
  • Scalp: Twice weekly in a short- contact fashion (up to 10 min application, then washing)
  • Preferred regimen (5): Desonide 0.05% lotion bid on scalp and other areas
  • 3. Lithium salts

Plant-based treatments

The World Health Organization mentions Aloe vera gel as a yet to be scientifically proven traditional medicine treatment for Seborrhoeic dermatitis.[14]

Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

Related Chapter

External Links

References

  1. Soares RC, Zani MB, Arruda AC, Arruda LH, Paulino LC (2015). "Malassezia intra-specific diversity and potentially new species in the skin microbiota from Brazilian healthy subjects and seborrheic dermatitis patients". PLoS One. 10 (2): e0117921. doi:10.1371/journal.pone.0117921. PMC 4335070. PMID 25695430.
  2. Hay R, Graham-Brown R (1997). "Dandruff and seborrheic dermatitis: causes and management". Clin Exp Dermatol. 22 (1): 3–6. doi:10.1046/j.1365-2230.1997.d01-231.x. PMID 9330043.
  3. Nowicki R (2006). "[Modern management of dandruff]". Pol Merkur Lekarski. 20 (115): 121–4. PMID 16617752.
  4. Am Fam Physician 2000;61:2703-10,2713-4
  5. Janniger C, Schwartz R (1995). "Seborrheic dermatitis". Am Fam Physician. 52 (1): 149–55, 159–60. PMID 7604759.
  6. Parry M, Sharpe G (1998). "Seborrheic dermatitis is not caused by an altered immune response to Malassezia yeast". Br J Dermatol. 139 (2): 254–63. doi:10.1046/j.1365-2133.1998.02362.x. PMID 9767239.
  7. "MedlinePlus Medical Encyclopedia: Hypervitaminosis A". www.nlm.nih.gov. Retrieved 2008-03-19.
  8. 8.0 8.1 8.2 "Seborrheic Dermatitis: An Overview - July 1, 2006 -- American Family Physician". www.aafp.org. Retrieved 2008-03-19.
  9. "eMedicine - Nutritional Neuropathy : Article by R Andrew Sewell". www.emedicine.com. Retrieved 2008-03-19.
  10. Hastings GB, Leathar DS, Scott AC (1988). "Scottish attitudes to AIDS". Br Med J (Clin Res Ed). 296 (6627): 991–2. PMC 2545449. PMID 3129121.
  11. Lewak N (1974). "Letter: Mythology and SIDS". N Engl J Med. 291 (14): 740–1. doi:10.1056/NEJM197410032911423. PMID 4852869.
  12. Dunic I, Vesic S, Jevtovic DJ (2004). "Oral candidiasis and seborrheic dermatitis in HIV-infected patients on highly active antiretroviral therapy". HIV Med. 5 (1): 50–4. PMID 14731170.
  13. Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL; et al. (2014). "Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America". Clin Infect Dis. 59 (2): 147–59. doi:10.1093/cid/ciu296. PMID 24947530.
  14. "WHO Monographs on Selected Medicinal Plants - Volume 1: Aloe Vera Gel". www.who.int. Retrieved 2008-03-18.
  15. 15.0 15.1 15.2 15.3 15.4 15.5 15.6 "The Green Pharmacy: New Discoveries ... - Google Book Search". books.google.com. Retrieved 2008-03-19.