Disseminated intravascular coagulation history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History

Symptoms

Symptoms of DIC vary depending on the magnitude of the imbalance of hemostasis, type of the disease, and the underlying cause. Common manifestations of DIC include bleeding and/or thrombosis with the resulting end organ damage. Patients with acute DIC typically present with bleeding symptoms ranging from oozing from venipuncture sites, petechiae, and ecchymoses; whereas chronic DIC is often associated with hypercoagulable states and thromboembolic complications.

Bleeding Symptoms

  • Petechiae
  • Ecchymoses
  • Blood oozing from wound sites, intravenous lines, catheters, mucosal surfaces
  • Hemorrhage involving gastrointestinal tract, lungs, or central nervous system

Thrombosis Symptoms

  • Venous thromboembolism
  • Arterial thrombosis with tissue or organ ischemia
  • Cerebral embolism

Organ Dysfunction

  • Symptoms of acute kidney injury
  • Decreased urinary output
  • Edema
  • Nausea
  • Fatigue
  • Symptoms of hepatic dysfunction
  • Jaundice
  • Nausea
  • Abdominal pain and swelling
  • Symptoms of acute lung injury
  • Hemoptysis
  • Dyspnea
  • Symptoms of neurologic dysfunction
  • Coma
  • Delirium
  • Focal neurologic deficits
  • Symptoms of adrenal insufficiency

References

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