Methocarbamol (injection)

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Methocarbamol (injection)
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

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Overview

Methocarbamol (injection) is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties that is FDA approved for the treatment of rest, physical therapy, and can be used as an adjunct to other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. Common adverse reactions include dizziness, headache, lightheadedness, somnolence.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

The injectable form of methocarbamol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Methocarbamol does not directly relax tense skeletal muscles in man.

Dosage

Total adult dosage should not exceed 30 mL (3 vials) a day for more than 3 consecutive days except in the treatment of tetanus. If the condition persists, a like course may be repeated after a drug-free interval of 48 hours. Dosage and frequency of injection should be based on the severity of the condition being treated and therapeutic response noted.

For the relief of symptoms of moderate degree, one dose of 1 gram (one 10 mL vial) may be adequate. Ordinarily this injection need not be repeated, as the administration of the oral form will usually sustain the relief initiated by the injection. For the severest cases or in postoperative conditions in which oral administration is not feasible, additional doses of 1 gram may be repeated every 8 hours up to a maximum of 3 g/day for no more than 3 consecutive days.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Methocarbamol (injection) in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Methocarbamol (injection) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Indications

  • Tetanus

Dosage

A minimum initial dose of 15 mg/kg or 500 mg/m2 is recommended. This dosage may be repeated every six hours, if required. The total dose should not exceed 1.8 g/m2 for 3 consecutive days. The maintenance dosage may be given by injection into tubing or by I.V. infusion with an appropriate quantity of fluid. See directions for I.V. use.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Methocarbamol (injection) in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Methocarbamol (injection) in pediatric patients.

Contraindications

  • Condition1

Warnings

  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Methocarbamol (injection) in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Methocarbamol (injection) in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Methocarbamol (injection) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Methocarbamol (injection) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Methocarbamol (injection) with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Methocarbamol (injection) with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Methocarbamol (injection) with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Methocarbamol (injection) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Methocarbamol (injection) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Methocarbamol (injection) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Methocarbamol (injection) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Methocarbamol (injection) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Methocarbamol (injection) in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Intramuscular
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Methocarbamol (injection) in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Methocarbamol (injection) in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Methocarbamol (injection) in the drug label.

Pharmacology

There is limited information regarding Methocarbamol (injection) Pharmacology in the drug label.

Mechanism of Action

Structure

File:Methocarbamol (injection)01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Methocarbamol (injection) in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Methocarbamol (injection) in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Methocarbamol (injection) in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Methocarbamol (injection) in the drug label.

How Supplied

Storage

There is limited information regarding Methocarbamol (injection) Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Patient Counseling Information of Methocarbamol (injection) in the drug label.

Precautions with Alcohol

  • Alcohol-Methocarbamol (injection) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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