Scoliosis pathophysiology

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Scoliosis Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pathophysiology

Genetics

In the case of the most common form of scoliosis, Adolescent Idiopathic Scoliosis, there is a clear Mendelian inheritance but with incomplete penetrance.

In April 2007, researchers at Texas Scottish Rite Hospital for Children identified the first gene associated with idiopathic scoliosis, CHD7. The medical breakthrough was the result of a 10-year study and is outlined in the May 2007 issue of the American Journal of Human Genetics.[1]

Associated conditions

Scoliosis is sometimes associated with other conditions such as

However, the majority of people with adolescent scoliosis have no pain or other abnormalities.

References

  1. Texas Scottish Rite Hospital for Children Research: Scoliosis Research

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