Polymyositis and dermatomyositis risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
Common risk factors in the development of polymyositis and dermatomyositis include environmental factors such as infection, malignancy, and drug toxicities from statins or immune checkpoint inhibitors.
Risk Factors
- Common risk factors in the development of polymyositis and dermatomyositis include environmental factors such as infection, malignancy, and drug toxicities from statins or immune checkpoint inhibitors.[1]
Common Risk Factors
- Common risk factors in the development of polymyositis and dermatomyositis include:
- Viral infections such as:
- Coxsackie B virus
- Parvovirus
- Enterovirus
- Human T-cell lymphotropic virus (HTLV-1)
- Human immunodeficiency virus (HIV)
- Epstein-Barr virus (EBV)
- Adenovirus
- Influenza
- Malignancy such as:
- Ovarian
- Lung
- Gastric
- Colorectal
- Pancreatic
- Non-Hodgkin’s lymphoma
- Drugs such as:
- Statins
- Immune checkpoint inhibitors such as:
- Ipilimumab
- Pembrolizumab
- Interferon-alpha
- IL-2 therapy
- Viral infections such as:
Less Common Risk Factors
- Less common risk factors in the development of polymyositis and dermatomyositis include:
- Maternal smoking during pregnancy (risk factor for a juvenile dermatomyositis)[2]
References
- ↑ Adler BL, Christopher-Stine L (February 2018). "Triggers of inflammatory myopathy: insights into pathogenesis". Discov Med. 25 (136): 75–83. PMID 29579414.
- ↑ Schiffenbauer, Adam; Faghihi-Kashani, Sara; O’Hanlon, Terrence P.; Flegel, Willy A.; Adams, Sharon D.; Targoff, Ira N.; Oddis, Chester V.; Ytterberg, Steven R.; Aggarwal, Rohit; Christopher-Stine, Lisa; Shamim, Ejaz A.; Dellaripa, Paul F.; Danoff, Sonye K.; Mammen, Andrew; Miller, Frederick W. (2018). "The impact of cigarette smoking on the clinical and serological phenotypes of polymyositis and dermatomyositis". Seminars in Arthritis and Rheumatism. doi:10.1016/j.semarthrit.2018.02.003. ISSN 0049-0172.