SLC34A3

Solute carrier family 34 (sodium phosphate), member 3
Identifiers
Symbols	SLC34A3 ; FLJ38680; HHRH; NPTIIc
External IDs	Template:OMIM5 Template:MGI HomoloGene: 15444
Gene ontology Molecular function Template:GNF GOTemplate:GNF GOTemplate:GNF GOTemplate:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Solute carrier family 34 (sodium phosphate), member 3, also known as SLC34A3, is a human gene.

SLC34A3 contributes to the maintenance of inorganic phosphate concentration at the kidney (Segawa et al., 2002).[supplied by OMIM] Both NPT2a and SLC34A3 (NPT2c) are regulated in a similar fashion by parathyroid hormone (PTH), FGF23, and dietary phosphate. Phosphate deprivation increases NPT2a and NPT2c expression. The relative expression of NPT2a is an order of magnitude higher than that of NPT2c in kidneys of organisms maintained on a normal phosphate diet. Normal animals exhibit a more robust increase in NPT2c than in NPT2a in response to phosphate deprivation. NPT2c is regulated by FGF23 and probably downregulated by PTH. As such SLC34A3 is involved in phosphate homeostasis.

See also

• SLC34A3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

• Forster IC, Hernando N, Biber J, Murer H (2006). "Proximal tubular handling of phosphate: A molecular perspective". Kidney Int. 70 (9): 1548–59. doi:10.1038/sj.ki.5001813. PMID 16955105.CS1 maint: Multiple names: authors list (link)
• Yamamoto T, Michigami T, Aranami F; et al. (2007). "Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene type IIc and osteoblastic function". J. Bone Miner. Metab. 25 (6): 407–13. doi:10.1007/s00774-007-0776-6. PMID 17968493.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lorenz-Depiereux B, Benet-Pages A, Eckstein G; et al. (2007). "Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3". Am. J. Hum. Genet. 78 (2): 193–201. doi:10.1086/499410. PMID 16358215.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bergwitz C, Roslin NM, Tieder M; et al. (2007). "SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis". Am. J. Hum. Genet. 78 (2): 179–92. doi:10.1086/499409. PMID 16358214.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ehnes C, Forster IC, Bacconi A; et al. (2005). "Structure-function relations of the first and fourth extracellular linkers of the type IIa Na+/Pi cotransporter: II. Substrate interaction and voltage dependency of two functionally important sites". J. Gen. Physiol. 124 (5): 489–503. doi:10.1085/jgp.200409061. PMID 15504899.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gisler SM, Pribanic S, Bacic D; et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Segawa H, Kaneko I, Takahashi A; et al. (2002). "Growth-related renal type II Na/Pi cotransporter". J. Biol. Chem. 277 (22): 19665–72. doi:10.1074/jbc.M200943200. PMID 11880379.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.