OLIG2

Oligodendrocyte lineage transcription factor 2
Identifiers
Symbols	OLIG2 ; BHLHB1; OLIGO2; PRKCBP2; RACK17
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4241
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE OLIG2 213824 at tn.png
File:PBB GE OLIG2 213825 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Oligodendrocyte lineage transcription factor 2, also known as OLIG2, is a human gene.

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.

Further reading

• Wang J, Jani-Sait SN, Escalon EA; et al. (2000). "The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3497–502. PMID 10737801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marie Y, Sanson M, Mokhtari K; et al. (2001). "OLIG2 as a specific marker of oligodendroglial tumour cells". Lancet. 358 (9278): 298–300. PMID 11498220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu QR, Park JK, Noll E; et al. (2001). "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10851–6. doi:10.1073/pnas.181340798. PMID 11526205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun T, Dong H, Wu L; et al. (2003). "Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex". J. Neurosci. 23 (29): 9547–56. PMID 14573534.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukuda S, Kondo T, Takebayashi H, Taga T (2004). "Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2 on the astrocytic differentiation pathway". Cell Death Differ. 11 (2): 196–202. doi:10.1038/sj.cdd.4401332. PMID 14576772.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ligon KL, Alberta JA, Kho AT; et al. (2004). "The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas". J. Neuropathol. Exp. Neurol. 63 (5): 499–509. PMID 15198128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hori Y, Gu X, Xie X, Kim SK (2006). "Differentiation of insulin-producing cells from human neural progenitor cells". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMID 15839736.CS1 maint: Multiple names: authors list (link)
• Lin YW, Deveney R, Barbara M; et al. (2005). "OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1". Cancer Res. 65 (16): 7151–8. doi:10.1158/0008-5472.CAN-05-1400. PMID 16103065.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jakovcevski I, Zecevic N (2006). "Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS". J. Neurosci. 25 (44): 10064–73. doi:10.1523/JNEUROSCI.2324-05.2005. PMID 16267213.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun T, Hafler BP, Kaing S; et al. (2006). "Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube". Dev. Biol. 292 (1): 152–64. doi:10.1016/j.ydbio.2005.12.047. PMID 16469306.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tabu K, Ohnishi A, Sunden Y; et al. (2006). "A novel function of OLIG2 to suppress human glial tumor cell growth via p27Kip1 transactivation". J. Cell. Sci. 119 (Pt 7): 1433–41. doi:10.1242/jcs.02854. PMID 16554441.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wissmüller S, Kosian T, Wolf M; et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMID 16582099.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ligon KL, Kesari S, Kitada M; et al. (2006). "Development of NG2 neural progenitor cells requires Olig gene function". Proc. Natl. Acad. Sci. U.S.A. 103 (20): 7853–8. doi:10.1073/pnas.0511001103. PMID 16682644.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Georgieva L, Moskvina V, Peirce T; et al. (2006). "Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 103 (33): 12469–74. doi:10.1073/pnas.0603029103. PMID 16891421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruf N, Martelli M, Weschke B, Uhlenberg B (2007). "Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (3): 365–6. doi:10.1002/ajmg.b.30434. PMID 17171653.CS1 maint: Multiple names: authors list (link)

External links

• OLIG2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.