PRAM1

PML-RARA regulated adaptor molecule 1
Identifiers
Symbols	PRAM1 ; MGC39864; PRAM-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 12963
Gene ontology Molecular function Template:GNF GO
RNA expression pattern
File:PBB GE PRAM1 gnf1h00620 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

PML-RARA regulated adaptor molecule 1, also known as PRAM1, is a human gene.

The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).

Further reading

• Boddy MN, Howe K, Etkin LD; et al. (1996). "PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia". Oncogene. 13 (5): 971–82. PMID 8806687.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cao T, Duprez E, Borden KL; et al. (1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell. Sci. 111 ( Pt 10): 1319–29. PMID 9570750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moog-Lutz C, Peterson EJ, Lutz PG; et al. (2001). "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells". J. Biol. Chem. 276 (25): 22375–81. doi:10.1074/jbc.M011683200. PMID 11301322.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Khan MM, Nomura T, Kim H; et al. (2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Mol. Cell. 7 (6): 1233–43. PMID 11430826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clemens RA, Newbrough SA, Chung EY; et al. (2004). "PRAM-1 is required for optimal integrin-dependent neutrophil function". Mol. Cell. Biol. 24 (24): 10923–32. doi:10.1128/MCB.24.24.10923-10932.2004. PMID 15572693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Denis FM, Benecke A, Di Gioia Y; et al. (2005). "PRAM-1 potentiates arsenic trioxide-induced JNK activation". J. Biol. Chem. 280 (10): 9043–8. doi:10.1074/jbc.M413564200. PMID 15637062.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rossi V, Levati L, Biondi A (2006). "Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR". Methods Mol. Med. 125: 115–26. PMID 16502581.CS1 maint: Multiple names: authors list (link)
• Mokany E, Todd AV, Fuery CJ, Applegate TL (2006). "Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR". Methods Mol. Med. 125: 127–47. PMID 16502582.CS1 maint: Multiple names: authors list (link)
• Heuer K, Sylvester M, Kliche S; et al. (2006). "Lipid-binding hSH3 domains in immune cell adapter proteins". J. Mol. Biol. 361 (1): 94–104. doi:10.1016/j.jmb.2006.06.004. PMID 16831444.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)