WNK4

WNK lysine deficient protein kinase 4
Identifiers
Symbols	WNK4 ; PHA2B; PRKWNK4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 13020
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WNK lysine deficient protein kinase 4, also known as WNK4, is a human gene.

The WNK4 gene encodes a serine-threonine kinase expressed in distal nephron.[supplied by OMIM]

Further reading

• Subramanya AR, Yang CL, McCormick JA, Ellison DH (2006). "WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron". Kidney Int. 70 (4): 630–4. doi:10.1038/sj.ki.5001634. PMID 16820787.CS1 maint: Multiple names: authors list (link)
• Peng JB, Warnock DG (2007). "WNK4-mediated regulation of renal ion transport proteins". Am. J. Physiol. Renal Physiol. 293 (4): F961–73. doi:10.1152/ajprenal.00192.2007. PMID 17634397.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Wilson FH, Disse-Nicodème S, Choate KA; et al. (2001). "Human hypertension caused by mutations in WNK kinases". Science. 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Veríssimo F, Jordan P (2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene. 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656.
• Wilson FH, Kahle KT, Sabath E; et al. (2003). "Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 680–4. doi:10.1073/pnas.242735399. PMID 12515852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Erlich PM, Cui J, Chazaro I; et al. (2003). "Genetic variants of WNK4 in whites and African Americans with hypertension". Hypertension. 41 (6): 1191–5. doi:10.1161/01.HYP.0000070025.30572.91. PMID 12719438.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Piechotta K, Garbarini N, England R, Delpire E (2004). "Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase". J. Biol. Chem. 278 (52): 52848–56. doi:10.1074/jbc.M309436200. PMID 14563843.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kahle KT, Gimenez I, Hassan H; et al. (2004). "WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia". Proc. Natl. Acad. Sci. U.S.A. 101 (7): 2064–9. doi:10.1073/pnas.0308434100. PMID 14769928.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamauchi K, Rai T, Kobayashi K; et al. (2004). "Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4690–4. doi:10.1073/pnas.0306924101. PMID 15070779.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamide K, Takiuchi S, Tanaka C; et al. (2004). "Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes". Am. J. Hypertens. 17 (5 Pt 1): 446–9. doi:10.1016/j.amjhyper.2003.12.020. PMID 15110905.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mayan H, Munter G, Shaharabany M; et al. (2004). "Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation". J. Clin. Endocrinol. Metab. 89 (8): 4025–30. doi:10.1210/jc.2004-0037. PMID 15292344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fu Y, Subramanya A, Rozansky D, Cohen DM (2006). "WNK kinases influence TRPV4 channel function and localization". Am. J. Physiol. Renal Physiol. 290 (6): F1305–14. doi:10.1152/ajprenal.00391.2005. PMID 16403833.CS1 maint: Multiple names: authors list (link)
• Cai H, Cebotaru V, Wang YH; et al. (2006). "WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells". Kidney Int. 69 (12): 2162–70. doi:10.1038/sj.ki.5000333. PMID 16688122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang Y, Ferguson WB, Peng JB (2007). "WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4". Am. J. Physiol. Renal Physiol. 292 (2): F545–54. doi:10.1152/ajprenal.00187.2006. PMID 17018846.CS1 maint: Multiple names: authors list (link)
• Ring AM, Leng Q, Rinehart J; et al. (2007). "An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 4025–9. doi:10.1073/pnas.0611728104. PMID 17360471.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)