SMURF2

SMAD specific E3 ubiquitin protein ligase 2
File:PBB Protein SMURF2 image.jpg PDB rendering based on 1zvd.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1zvd​, 2djy​
Identifiers
Symbols	SMURF2 ; DKFZp686F0270; MGC138150
External IDs	Template:OMIM5 Template:MGI HomoloGene: 41490
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SMURF2 205596 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SMAD specific E3 ubiquitin protein ligase 2, also known as SMURF2, is a human gene.

Further reading

• Lin X, Liang M, Feng XH (2001). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling". J. Biol. Chem. 275 (47): 36818–22. doi:10.1074/jbc.C000580200. PMID 11016919.CS1 maint: Multiple names: authors list (link)
• Zhang Y, Chang C, Gehling DJ; et al. (2001). "Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 974–9. doi:10.1073/pnas.98.3.974. PMID 11158580.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kavsak P, Rasmussen RK, Causing CG; et al. (2001). "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation". Mol. Cell. 6 (6): 1365–75. PMID 11163210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonni S, Wang HR, Causing CG; et al. (2001). "TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation". Nat. Cell Biol. 3 (6): 587–95. doi:10.1038/35078562. PMID 11389444.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Subramaniam V, Li H, Wong M; et al. (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase". Br. J. Cancer. 89 (8): 1538–44. doi:10.1038/sj.bjc.6601301. PMID 14562029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Asano Y, Ihn H, Yamane K; et al. (2004). "Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts". J. Clin. Invest. 113 (2): 253–64. doi:10.1172/JCI200416269. PMID 14722617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.
• Jin YH, Jeon EJ, Li QL; et al. (2004). "Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation". J. Biol. Chem. 279 (28): 29409–17. doi:10.1074/jbc.M313120200. PMID 15138260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang H, Cohen SN (2005). "Smurf2 up-regulation activates telomere-dependent senescence". Genes Dev. 18 (24): 3028–40. doi:10.1101/gad.1253004. PMID 15574587.
• Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohashi N, Yamamoto T, Uchida C; et al. (2005). "Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta". FEBS Lett. 579 (12): 2557–63. doi:10.1016/j.febslet.2005.03.069. PMID 15862290.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogunjimi AA, Briant DJ, Pece-Barbara N; et al. (2005). "Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain". Mol. Cell. 19 (3): 297–308. doi:10.1016/j.molcel.2005.06.028. PMID 16061177.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chong PA, Lin H, Wrana JL, Forman-Kay JD (2006). "An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2". J. Biol. Chem. 281 (25): 17069–75. doi:10.1074/jbc.M601493200. PMID 16641086.CS1 maint: Multiple names: authors list (link)
• Wiesner S, Ogunjimi AA, Wang HR; et al. (2007). "Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain". Cell. 130 (4): 651–62. doi:10.1016/j.cell.2007.06.050. PMID 17719543.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)