CDC16

Cell division cycle 16 homolog (S. cerevisiae)
Identifiers
Symbols	CDC16 ; APC6
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2899
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cell division cycle 16 homolog (S. cerevisiae), also known as CDC16, is a human gene.

This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Further reading

• Tugendreich S, Tomkiel J, Earnshaw W, Hieter P (1995). "CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition". Cell. 81 (2): 261–8. PMID 7736578.CS1 maint: Multiple names: authors list (link)
• Ollendorff V, Donoghue DJ (1998). "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex". J. Biol. Chem. 272 (51): 32011–8. PMID 9405394.
• Yu H, Peters JM, King RW; et al. (1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. PMID 9469815.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kallio M, Weinstein J, Daum JR; et al. (1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". J. Cell Biol. 141 (6): 1393–406. PMID 9628895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grossberger R, Gieffers C, Zachariae W; et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. PMID 10318877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan GK, Jablonski SA, Sudakin V; et al. (1999). "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC". J. Cell Biol. 146 (5): 941–54. PMID 10477750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gieffers C, Peters BH, Kramer ER; et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. PMID 10500174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gmachl M, Gieffers C, Podtelejnikov AV; et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. PMID 10922056.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jörgensen PM, Gräslund S, Betz R; et al. (2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1–2): 51–9. PMID 11179667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stroschein SL, Bonni S, Wrana JL, Luo K (2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. 15 (21): 2822–36. doi:10.1101/gad.912901. PMID 11691834.CS1 maint: Multiple names: authors list (link)
• Yasui K, Arii S, Zhao C; et al. (2002). "TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas". Hepatology. 35 (6): 1476–84. doi:10.1053/jhep.2002.33683. PMID 12029633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ (2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". J. Cell Biol. 158 (5): 841–7. doi:10.1083/jcb.200201135. PMID 12196507.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Q, Moyret-Lalle C, Couzon F; et al. (2003). "Alterations of anaphase-promoting complex genes in human colon cancer cells". Oncogene. 22 (10): 1486–90. doi:10.1038/sj.onc.1206224. PMID 12629511.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vodermaier HC, Gieffers C, Maurer-Stroh S; et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. PMID 12956947.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kraft C, Herzog F, Gieffers C; et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". EMBO J. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMID 14657031.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)