TAF10

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
Identifiers
Symbols	TAF10 ; TAF2A; TAF2H; TAFII30
External IDs	Template:OMIM5 HomoloGene: 86916
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TAF10 200055 at tn.png
File:PBB GE TAF10 200056 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa, also known as TAF10, is a human gene.

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs.

Further reading

• Mengus G, May M, Jacq X; et al. (1995). "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID". EMBO J. 14 (7): 1520–31. PMID 7729427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou Q, Sharp PA (1995). "Novel mechanism and factor for regulation by HIV-1 Tat". EMBO J. 14 (2): 321–8. PMID 7835343.
• Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro". J. Biol. Chem. 270 (5): 2274–83. PMID 7836461.CS1 maint: Multiple names: authors list (link)
• Jacq X, Brou C, Lutz Y; et al. (1994). "Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor". Cell. 79 (1): 107–17. PMID 7923369.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188–99. PMID 7933101.CS1 maint: Multiple names: authors list (link)
• Kashanchi F, Piras G, Radonovich MF; et al. (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295–9. doi:10.1038/367295a0. PMID 8121496.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheer E, Mattei MG, Jacq X; et al. (1996). "Organization and chromosomal localization of the gene (TAF2H) encoding the human TBP-associated factor II 30 (TAFII30)". Genomics. 29 (1): 269–72. doi:10.1006/geno.1995.1243. PMID 8530084.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• vom Baur E, Zechel C, Heery D; et al. (1996). "Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1". EMBO J. 15 (1): 110–24. PMID 8598193.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Z, Morris GF, Rice AP; et al. (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (2): 128–38. PMID 8680883.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pendergrast PS, Morrison D, Tansey WP, Hernandez N (1996). "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly". J. Virol. 70 (8): 5025–34. PMID 8764009.CS1 maint: Multiple names: authors list (link)
• Kashanchi F, Khleif SN, Duvall JF; et al. (1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex". J. Virol. 70 (8): 5503–10. PMID 8764062.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. PMID 8849451.
• García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. PMID 9054383.CS1 maint: Multiple names: authors list (link)
• Chéhensse V, Boulvin C, Luce S; et al. (1997). "Assignment of the human TAFII30 gene (TAF2H) to human chromosome band 11p15.3 using somatic cell hybrids". Cytogenet. Cell Genet. 76 (1–2): 41–2. PMID 9154123.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogryzko VV, Kotani T, Zhang X; et al. (1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. PMID 9674425.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vassilev A, Yamauchi J, Kotani T; et al. (1999). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Mol. Cell. 2 (6): 869–75. PMID 9885574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brand M, Yamamoto K, Staub A, Tora L (1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". J. Biol. Chem. 274 (26): 18285–9. PMID 10373431.CS1 maint: Multiple names: authors list (link)
• Metzger D, Scheer E, Soldatov A, Tora L (1999). "Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes". EMBO J. 18 (17): 4823–34. doi:10.1093/emboj/18.17.4823. PMID 10469660.CS1 maint: Multiple names: authors list (link)
• Brand M, Moggs JG, Oulad-Abdelghani M; et al. (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMID 11406595.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gangloff YG, Pointud JC, Thuault S; et al. (2001). "The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger". Mol. Cell. Biol. 21 (15): 5109–21. doi:10.1128/MCB.21.15.5109-5121.2001. PMID 11438666.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)