MFN1

Mitofusin 1
Identifiers
Symbols	MFN1 ; DKFZp762F247; FLJ20693; MGC41806; hfzo1; hfzo2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11481
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mitofusin 1, also known as MFN1, is a human gene.

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.

Further reading

• Pawlikowska P, Orzechowski A (2007). "[Role of transmembrane GTPases in mitochondrial morphology and activity]". Postepy Biochem. 53 (1): 53–9. PMID 17718388.
• Adams MD, Kerlavage AR, Fields C, Venter JC (1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat. Genet. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434.CS1 maint: Multiple names: authors list (link)
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hales KG, Fuller MT (1997). "Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase". Cell. 90 (1): 121–9. PMID 9230308.
• Santel A, Fuller MT (2001). "Control of mitochondrial morphology by a human mitofusin". J. Cell. Sci. 114 (Pt 5): 867–74. PMID 11181170.
• Chung JG, Yeh KT, Wu SL; et al. (2002). "Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display". Cancer Res. 61 (24): 8873–9. PMID 11751411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rojo M, Legros F, Chateau D, Lombès A (2003). "Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo". J. Cell. Sci. 115 (Pt 8): 1663–74. PMID 11950885.CS1 maint: Multiple names: authors list (link)
• Legros F, Lombès A, Frachon P, Rojo M (2003). "Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins". Mol. Biol. Cell. 13 (12): 4343–54. doi:10.1091/mbc.E02-06-0330. PMID 12475957.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Santel A, Frank S, Gaume B; et al. (2004). "Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells". J. Cell. Sci. 116 (Pt 13): 2763–74. doi:10.1242/jcs.00479. PMID 12759376.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L (2004). "OPA1 requires mitofusin 1 to promote mitochondrial fusion". Proc. Natl. Acad. Sci. U.S.A. 101 (45): 15927–32. doi:10.1073/pnas.0407043101. PMID 15509649.CS1 maint: Multiple names: authors list (link)
• Cartoni R, Léger B, Hock MB; et al. (2005). "Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise". J. Physiol. (Lond.). 567 (Pt 1): 349–58. doi:10.1113/jphysiol.2005.092031. PMID 15961417.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)