SP110
| SP110 nuclear body protein | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SP110 ; FLJ22835; IFI41; IFI75; VODI | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 82192 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SP110 209761 s at tn.png | |||||||||||
| File:PBB GE SP110 208392 x at tn.png | |||||||||||
| File:PBB GE SP110 208012 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
SP110 nuclear body protein, also known as SP110, is a human gene.[1]
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.[1]
References
Further reading
- Kadereit S, Gewert DR, Galabru J; et al. (1993). "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins". J. Biol. Chem. 268 (32): 24432–41. PMID 7693701.
- Welsh GI, Kadereit S, Coccia EM; et al. (1999). "Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin". Exp. Cell Res. 250 (1): 62–74. doi:10.1006/excr.1999.4505. PMID 10388521.
- Bloch DB, Nakajima A, Gulick T; et al. (2000). "Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator". Mol. Cell. Biol. 20 (16): 6138–46. PMID 10913195.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Izmailova E, Bertley FM, Huang Q; et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
- Watashi K, Hijikata M, Tagawa A; et al. (2003). "Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus". Mol. Cell. Biol. 23 (21): 7498–509. PMID 14559998.
- Nicewonger J, Suck G, Bloch D, Swaminathan S (2004). "Epstein-Barr virus (EBV) SM protein induces and recruits cellular Sp110b to stabilize mRNAs and enhance EBV lytic gene expression". J. Virol. 78 (17): 9412–22. doi:10.1128/JVI.78.17.9412-9422.2004. PMID 15308735.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Roscioli T, Cliffe ST, Bloch DB; et al. (2006). "Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease". Nat. Genet. 38 (6): 620–2. doi:10.1038/ng1780. PMID 16648851.
- Tosh K, Campbell SJ, Fielding K; et al. (2006). "Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa". Proc. Natl. Acad. Sci. U.S.A. 103 (27): 10364–8. doi:10.1073/pnas.0603340103. PMID 16803959.
- Thye T, Browne EN, Chinbuah MA; et al. (2006). "No associations of human pulmonary tuberculosis with Sp110 variants". J. Med. Genet. 43 (7): e32. doi:10.1136/jmg.2005.037960. PMID 16816019.
- Warren EH, Vigneron NJ, Gavin MA; et al. (2006). "An antigen produced by splicing of noncontiguous peptides in the reverse order". Science. 313 (5792): 1444–7. doi:10.1126/science.1130660. PMID 16960008.
- Szeszko JS, Healy B, Stevens H; et al. (2007). "Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis". Hum. Genet. 121 (2): 155–60. doi:10.1007/s00439-006-0293-z. PMID 17149599.
- Babb C, Keet EH, van Helden PD, Hoal EG (2007). "SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population". Hum. Genet. 121 (3–4): 521–2. doi:10.1007/s00439-007-0335-1. PMID 17287948.
- Cliffe ST, Wong M, Taylor PJ; et al. (2007). "The first prenatal diagnosis for veno-occlusive disease and immunodeficiency syndrome, an autosomal recessive condition associated with mutations in SP110". Prenat. Diagn. 27 (7): 674–6. doi:10.1002/pd.1759. PMID 17510920.
- de la Fuente J, Manzano-Roman R, Blouin EF; et al. (2007). "Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells". BMC Infect. Dis. 7: 110. doi:10.1186/1471-2334-7-110. PMID 17883869.
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