REG1A

Regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)
File:PBB Protein REG1A image.jpg PDB rendering based on 1lit.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1lit​, 1qdd​
Identifiers
Symbols	REG1A ; REG; PSP; ICRF; MGC12447; P19; PSPS; PSPS1; PTP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68282
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE REG1A 209752 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein), also known as REG1A, is a human gene.

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.

Further reading

• De Reggi M, Gharib B (2002). "Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions". Curr. Protein Pept. Sci. 2 (1): 19–42. PMID 12369899.
• Itoh T, Tsuzuki H, Katoh T; et al. (1990). "Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae". FEBS Lett. 272 (1–2): 85–8. PMID 2226837.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watanabe T, Yonekura H, Terazono K; et al. (1990). "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene". J. Biol. Chem. 265 (13): 7432–9. PMID 2332435.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de la Monte SM, Ozturk M, Wands JR (1990). "Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain". J. Clin. Invest. 86 (3): 1004–13. PMID 2394826.CS1 maint: Multiple names: authors list (link)
• De Caro AM, Adrich Z, Fournet B; et al. (1989). "N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue". Biochim. Biophys. Acta. 994 (3): 281–4. PMID 2493268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giorgi D, Bernard JP, Rouquier S; et al. (1989). "Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis". J. Clin. Invest. 84 (1): 100–6. PMID 2525567.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stewart TA (1989). "The human reg gene encodes pancreatic stone protein". Biochem. J. 260 (2): 622–3. PMID 2764894.
• Terazono K, Yamamoto H, Takasawa S; et al. (1988). "A novel gene activated in regenerating islets". J. Biol. Chem. 263 (5): 2111–4. PMID 2963000.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rouimi P, Bonicel J, Rovery M, De Caro A (1987). "Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein". FEBS Lett. 216 (2): 195–9. PMID 3108036.CS1 maint: Multiple names: authors list (link)
• Rouimi P, de Caro J, Bonicel J; et al. (1988). "The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice". FEBS Lett. 229 (1): 171–4. PMID 3345835.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Montalto G, Bonicel J, Multigner L; et al. (1987). "Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein". Biochem. J. 238 (1): 227–32. PMID 3541906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• De Caro AM, Bonicel JJ, Rouimi P; et al. (1987). "Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice". Eur. J. Biochem. 168 (1): 201–7. PMID 3665916.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gross J, Carlson RI, Brauer AW; et al. (1986). "Isolation, characterization, and distribution of an unusual pancreatic human secretory protein". J. Clin. Invest. 76 (6): 2115–26. PMID 3908481.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perfetti R, Hawkins AL, Griffin CA; et al. (1994). "Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12". Genomics. 20 (2): 305–7. doi:10.1006/geno.1994.1173. PMID 8020983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Otonkoski T, Mally MI, Hayek A (1994). "Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells". Diabetes. 43 (9): 1164–6. PMID 8070617.CS1 maint: Multiple names: authors list (link)
• Moriizumi S, Watanabe T, Unno M; et al. (1994). "Isolation, structural determination and expression of a novel reg gene, human regI beta". Biochim. Biophys. Acta. 1217 (2): 199–202. PMID 8110835.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gharib B, Fox MF, Bartoli C; et al. (1993). "Human regeneration protein/lithostathine genes map to chromosome 2p12". Ann. Hum. Genet. 57 (Pt 1): 9–16. PMID 8333731.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bartoli C, Gharib B, Giorgi D; et al. (1993). "A gene homologous to the reg gene is expressed in the human pancreas". FEBS Lett. 327 (3): 289–93. PMID 8348956.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bertrand JA, Pignol D, Bernard JP; et al. (1996). "Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation". EMBO J. 15 (11): 2678–84. PMID 8654365.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Patard L, Stoven V, Gharib B; et al. (1997). "What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy". Protein Eng. 9 (11): 949–57. PMID 8961348.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)