Small ubiquitin-related modifier 1

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
File:PBB Protein SUMO1 image.jpg PDB rendering based on 1a5r.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1a5r​, 1tgz​, 1wyw​, 1y8r​, 1z5s​, 2asq​, 2bf8​, 2g4d​, 2io2​, 2iy0​, 2iy1​, 2pe6​
Identifiers
Symbols	SUMO1 ; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; SUMO-1; UBL1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2514
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SUMO1 208761 s at tn.png
File:PBB GE SUMO1 208762 at tn.png
File:PBB GE SUMO1 211069 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae), also known as SUMO1, is a human gene.

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.

Further reading

• Cookson MR (2003). "Pathways to Parkinsonism". Neuron. 37 (1): 7–10. PMID 12526767.
• Boddy MN, Howe K, Etkin LD; et al. (1996). "PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia". Oncogene. 13 (5): 971–82. PMID 8806687.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shen Z, Pardington-Purtymun PE, Comeaux JC; et al. (1997). "UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins". Genomics. 36 (2): 271–9. doi:10.1006/geno.1996.0462. PMID 8812453.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Okura T, Gong L, Kamitani T; et al. (1996). "Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin". J. Immunol. 157 (10): 4277–81. PMID 8906799.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shen Z, Pardington-Purtymun PE, Comeaux JC; et al. (1997). "Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system". Genomics. 37 (2): 183–6. doi:10.1006/geno.1996.0540. PMID 8921390.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matunis MJ, Coutavas E, Blobel G (1997). "A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex". J. Cell Biol. 135 (6 Pt 1): 1457–70. PMID 8978815.CS1 maint: Multiple names: authors list (link)
• Mahajan R, Delphin C, Guan T; et al. (1997). "A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2". Cell. 88 (1): 97–107. PMID 9019411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lapenta V, Chiurazzi P, van der Spek P; et al. (1997). "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family". Genomics. 40 (2): 362–6. doi:10.1006/geno.1996.4556. PMID 9119407.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamitani T, Nguyen HP, Yeh ET (1997). "Preferential modification of nuclear proteins by a novel ubiquitin-like molecule". J. Biol. Chem. 272 (22): 14001–4. PMID 9162015.CS1 maint: Multiple names: authors list (link)
• Mahajan R, Gerace L, Melchior F (1998). "Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association". J. Cell Biol. 140 (2): 259–70. PMID 9442102.CS1 maint: Multiple names: authors list (link)
• Howe K, Williamson J, Boddy N; et al. (1998). "The ubiquitin-homology gene PIC1: characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes". Genomics. 47 (1): 92–100. doi:10.1006/geno.1997.5091. PMID 9465300.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bayer P, Arndt A, Metzger S; et al. (1998). "Structure determination of the small ubiquitin-related modifier SUMO-1". J. Mol. Biol. 280 (2): 275–86. doi:10.1006/jmbi.1998.1839. PMID 9654451.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Desterro JM, Rodriguez MS, Hay RT (1998). "SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation". Mol. Cell. 2 (2): 233–9. PMID 9734360.CS1 maint: Multiple names: authors list (link)
• Juo P, Kuo CJ, Yuan J, Blenis J (1998). "Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade". Curr. Biol. 8 (18): 1001–8. PMID 9740801.CS1 maint: Multiple names: authors list (link)
• Kamitani T, Kito K, Nguyen HP; et al. (1998). "Identification of three major sentrinization sites in PML". J. Biol. Chem. 273 (41): 26675–82. PMID 9756909.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duprez E, Saurin AJ, Desterro JM; et al. (1999). "SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation". J. Cell. Sci. 112 ( Pt 3): 381–93. PMID 9885291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen A, Mannen H, Li SS (1999). "Characterization of mouse ubiquitin-like SMT3A and SMT3B cDNAs and gene/pseudogenes". Biochem. Mol. Biol. Int. 46 (6): 1161–74. PMID 9891849.CS1 maint: Multiple names: authors list (link)
• Okuma T, Honda R, Ichikawa G; et al. (1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liou ML, Liou HC (1999). "The ubiquitin-homology protein, DAP-1, associates with tumor necrosis factor receptor (p60) death domain and induces apoptosis". J. Biol. Chem. 274 (15): 10145–53. PMID 10187798.