Rubella pathophysiology

Jump to navigation Jump to search

Rubella Microchapters

Home

Patient Information

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Rubella from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Treatment

Medical Therapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Case Studies

Case #1

Rubella pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Rubella pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Rubella pathophysiology

CDC on Rubella pathophysiology

Rubella pathophysiology in the news

Blogs on Rubella pathophysiology

Directions to Hospitals Treating Rubella

Risk calculators and risk factors for Rubella pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fatimo Biobaku M.B.B.S [2]

Overview

Pathophysiology

The pathophysiology of rubella infection is not fully understood.[1] The pathophysiology of rubella infection involves the following processes:[1][2]

  • The transmission of infection is via person-person spread through droplets that are shed from respiratory secretions of infected persons.
  • Viral replication occurs in the respiratory epithelium, with subsequent spread of the virus to the regional lymph nodes.
  • Viremia ensues and subsequent seeding of viremia to multiple organs may occur (including the placenta in pregnant women, which results in congenital rubella syndrome).
  • The onset of viremia is usually between 8-9 days after exposure, peaking at 10-17 days.
  • The onset of rash usually occurs 16-18 days after exposure (around the peak of viremia).
  • Approximately 10 days after infection, viral shedding from the nasopharynx begins.
  • Viral shedding may continue 1 week before the rash appears to about 5-14 days after the disappearance of the rash.
  • The patient is most contagious 5 days before the onset of the rash to 6 days after the appearance of the rash.

References

  1. 1.0 1.1 Kliegman, Robert; Stanton, Bonita; St. Geme, Joseph; Schor, Nina (2016). "Chapter 247:Rubella". Nelson Textbook of Pediatrics Twentieth Edition. Elsevier. pp. 1548–1552. ISBN 978-1-4557-7566-8.
  2. Goldman, Lee; Schafer, Andrew (2016). "Chapter 368:Rubella (German Measles)". Goldman-Cecil Medicine, 25th Edition. Elsevier. pp. 2204–2206. ISBN 9781455750177.

Template:WH Template:WS