Sandbox g12

• Torsades de pointes risk stratification schedules for antimicrobial agents

• Schedule I (Highest TdP risk, potent IKr blockers, TdP risk >1%)

• Not available

• Schedule II (Significant risk for TdP, particularly when coadministered with CYP inhibitors, relatively potent IKr blockade)

• Not available

• Schedule III (Risk for TdP is described, IKr blockade, particularly when coadministered with CYP inhibitors)

• Clarithromycin
• Erythromycin
• Itraconazole
• Ketoconazole
• Pentamidine
• Sparfloxacin

• Schedule IV (Minimal risk for TdP, case reports of TdP, mild IKr blockade, may have CYP interactions)

• Fluconazole
• Gatifloxacin
• Gemifloxacin
• Grepafloxacin
• Levofloxacin
• Moxifloxacin
• Telithromycin
• Voriconazole

• Schedule V (Questionable/minimal risk for QT interval prolongation/TdP)

• Azithromycin
• Ciprofloxacin
• Sulfamethoxazole-Trimethoprim