Pertussis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]

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Natural history

Because neither vaccination nor infection confers long-term immunity, infection of adolescents and adults is also common [1] Most adults and adolescents who become infected with Bordetella pertussis have been vaccinated or infected years previously. When there is residual immunity from previous infection or immunization, symptoms may be milder, such as a prolonged cough without the other classic symptoms of pertussis.

The clinical course of the illness is divided into three stages: catarrhal, paroxysmal and convalescent.

Stage Duration Key features
Catarrhal Usually 7 - 10 days Low grade fever, coryza
Paroxysmal Lasts for 1 - 6 weeks Paroxysmal attacks, cyanosis at times
Convalescent Usually 7 - 10 days Gradual recovery, less paroxysmal coughs

Complications

This disease results in high morbidity and mortality in many countries every year. Complications of the disease[2] include

References

  1. Hewlett EL, Edwards KM (2005). "Pertussis--not just for kids". New Eng J Med. 352 (12): 1215–1222.
  2. "Pertussis: MedlinePlus Medical Encyclopedia".
  3. Mattoo S, Cherry JD (2005). "Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies". Clin Microbiol Rev. 18 (2): 326–82. PMID 15831828.

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