Tick-borne disease

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Tick bite with central black eschar

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Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]

Overview

Tick-borne diseases are diseases or illnesses transmitted by ticks. As the incidence of tick-borne illnesses increases and the geographic areas in which they are found expand, it becomes increasingly important that health professionals be able to distinguish the diverse, and often overlapping, clinical presentations of these diseases.

Pathophysiology

Tick-borne illnesses are caused by infection with a variety of pathogens, including rickettsia and other types of bacteria, viruses, and protozoa. Because ticks can harbor more than one disease-causing agent, patients can be infected with more than one pathogen at the same time, compounding the difficulty in diagnosis and treatment.

Major tick-borne diseases include:

  • Lyme disease
    • Organism: Borrelia burgdorferi sensu lato (bacterium)
    • Vector: deer tick (Ixodes scapularis (=I. dammini), I. pacificus, I. ricinus (Europe), I. persulcatus (Asia))
    • Endemic to: North America and Eurasia
  • Tick-borne meningoencephalitis
    • Organism: TBEV aka FSME virus, a flavivirus
    • Vector: deer tick (Ixodes scapularis)
    • Endemic to: Europe and Northern Asia
  • Rocky Mountain Spotted Fever
    • Organism: Rickettsia rickettsii
    • Vector: Dermacentor variabilis, D. andersoni
    • Region (US): East, South West
    • Vector: Amblyomma cajennense
    • Region (Brazil): São Paulo, Rio de Janeiro, Minas Gerais.
  • Babesiosis
    • Organism: Babesia microti, B. equi
    • Vector: I. scapularis, I. pacificus
    • Region (US): Northeast West Coast
  • Ehrlichiosis anaplasmosis (formerly human granulocytic ehrlichiosis or HGE)
    • Organism: Ehrlichia chaffeensis, E. equi
    • Vector: Amblyomma americanum, I. scapularis
    • Region (US): South-Atlantic South-Central
  • Relapsing fever
    • Organism: Borrelia species
    • Vector: Ornithodoros species
    • Region (US): West
  • Colorado tick fever
    • Organism: Coltivirus
    • Vector: D. andersoni
    • Region (US): West
  • Tularemia
    • Organism: Francisella tularensis, A. americanum
    • Organism: D. andersoni, D. variabilis
    • Region (US): Southeast, South-Central, West, Widespread
  • Tick paralysis
    • Cause: Toxin
    • Vector: D. andersoni, D. variabilis West
    • Region (US): East
  • Cytauxzoonosis
    • Organism: C. felis
    • Vector: D. variabilis (American Dog Tick)
    • Region (US): South, Southeast

Diagnosis

Symptoms

Symptoms can vary in severity and include:

Physical examination

A rash with a central black area (eschar)as shown in the photo is suggestive of a tick bite.

Laboratory evaluation

In general, specific laboratory tests are not available to rapidly diagnose tick-borne diseases.

Treatment

Due to their seriousness, antibiotic treatment is often justified based on clinical presentation alone. Doxycycline is often used to treat suspected tick borne-disease.


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