Acetaminophen overdose resident survival guide: Difference between revisions

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==Definition==
==Definition==
This section provides a short and straight to the point definition of the disease or symptom in one sentence.
[[Acetaminophen]] overdose/toxicity occurs when there is intentional, accidental, acute and/or chronic ingestion of supratherapeutic doses of [[acetaminophen]] ([[paracetamol]]).


==Causes==
It is the most widely used OTC (over the counter) analgesic in USA. It is available in the U.S market under the following brand names .
===Life Threatening Causes===
<div class="mw-collapsible-content">
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
<div class="mw-collapsible mw-collapsed">
* [[Life threatening cause 1]]
Tylenol
* [[Life threatening cause 2]]
Anacin-3
* [[Life threatening cause 3]]
Liquiprin
Percocet
Tempra
Cold and flu medicines.
Aceta
Actimin
Apacet
Aspirin Free Anacin
Atasol
Banesin
Dapa
Datril Extra-Strength
Feverall
Fibi
Genapap
Genebs,
Panadol </div></div>


===Common Causes===
====Common dosage forms and strengths====
* [[Common cause 1]]
 
* [[Common cause 2]]
#Suppository: 120 mg, 125 mg, 325 mg, 650 mg
* [[Common cause 3]]
#Chewable tablets: 80 mg
* [[Common cause 4]]
#Regular strength: 325 mg
* [[Common cause 5]]
#Extra strength: 500 mg
#Liquid: 160 mg/teaspoon
#Drops: 100 mg / mL, 120 mg / 2.5 mL
 
=====Toxic Dose====
 
The toxic dose of paracetamol is highly variable. In individuals over 6 years of age, single doses above 200&nbsp;mg/kg consumed over a single 24-hour period have a reasonable likelihood of causing toxicity. If an individual has consumed large quantities of paracetamol over a 48 hour period, a dose of above  6&nbsp;[[grams]] or 150&nbsp;mg/kg in the subsequent 24 hour period may cause toxicity.<ref name="clintox2006-dart">{{cite journal | author=Dart RC, Erdman AR, Olson KR, Christianson G, Manoguerra AS, Chyka PA, Caravati EM, Wax PM, Keyes DC, Woolf AD, Scharman EJ, Booze LL, Troutman WG; American Association of Poison Control Centers | title=Acetaminophen poisoning: an evidence-based consensus guideline for out-of- hospital management | journal=Clin Toxicol (Phila) | year=2006 | pages=1–18 | volume=44 | issue=1 | pmid= 16496488}}</ref>


==Management==
==Management==

Revision as of 17:32, 10 January 2014


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vidit Bhargava, M.B.B.S [2]

Definition

Acetaminophen overdose/toxicity occurs when there is intentional, accidental, acute and/or chronic ingestion of supratherapeutic doses of acetaminophen (paracetamol).

It is the most widely used OTC (over the counter) analgesic in USA. It is available in the U.S market under the following brand names .

Tylenol Anacin-3 Liquiprin Percocet Tempra Cold and flu medicines. Aceta Actimin Apacet Aspirin Free Anacin Atasol Banesin Dapa Datril Extra-Strength Feverall Fibi Genapap Genebs,

Panadol

Common dosage forms and strengths

  1. Suppository: 120 mg, 125 mg, 325 mg, 650 mg
  2. Chewable tablets: 80 mg
  3. Regular strength: 325 mg
  4. Extra strength: 500 mg
  5. Liquid: 160 mg/teaspoon
  6. Drops: 100 mg / mL, 120 mg / 2.5 mL

=Toxic Dose

The toxic dose of paracetamol is highly variable. In individuals over 6 years of age, single doses above 200 mg/kg consumed over a single 24-hour period have a reasonable likelihood of causing toxicity. If an individual has consumed large quantities of paracetamol over a 48 hour period, a dose of above 6 grams or 150 mg/kg in the subsequent 24 hour period may cause toxicity.[1]

Management

Shown below is an algorithm summarizing the approach to [[disease name]].

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

References


Template:WikiDoc Sources

  1. ↑ Dart RC, Erdman AR, Olson KR, Christianson G, Manoguerra AS, Chyka PA, Caravati EM, Wax PM, Keyes DC, Woolf AD, Scharman EJ, Booze LL, Troutman WG; American Association of Poison Control Centers (2006). "Acetaminophen poisoning: an evidence-based consensus guideline for out-of- hospital management". Clin Toxicol (Phila). 44 (1): 1–18. PMID 16496488.
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