Norfloxacin: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 28: | Line 28: | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
Norfloxacin inhibits bacterial deoxyribonucleic acid synthesis and is bactericidal. At the molecular level, three specific events are attributed to norfloxacin in E. coli cells: | |||
inhibition of the ATP-dependent DNA supercoiling reaction catalyzed by DNA gyrase, | |||
inhibition of the relaxation of supercoiled DNA, | |||
promotion of double-stranded DNA breakage. | |||
==References== | ==References== | ||
Revision as of 21:54, 8 January 2014
For patient information, click here.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Category
Fluoroquinolone
US Brand Names
NOROXIN®,CHIBROXIN®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Clinical Studies | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
Norfloxacin inhibits bacterial deoxyribonucleic acid synthesis and is bactericidal. At the molecular level, three specific events are attributed to norfloxacin in E. coli cells:
inhibition of the ATP-dependent DNA supercoiling reaction catalyzed by DNA gyrase, inhibition of the relaxation of supercoiled DNA, promotion of double-stranded DNA breakage.