Spectinomycin microbiology: Difference between revisions

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==Microbiology==
Spectinomycin hydrochloride is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit.


 
In vitro studies have shown spectinomycin hydrochloride to be active against most strains of [[Neisseria gonorrhoeae]] (minimum inhibitory concentration <7.5 to 20 mcg/mL).
<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = TROBICIN (SPECTINOMYCIN) [PHARMACIA AND UPJOHN, CO.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=becf7b7a-508c-44ff-add0-558a60fd0067 | publisher =  | date =  | accessdate = }}</ref>
Definitive in vitro studies have shown no cross-resistance of N. gonorrhoeae between spectinomycin hydrochloride and penicillin. The antibiotic is not significantly bound to plasma protein.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = TROBICIN (SPECTINOMYCIN) [PHARMACIA AND UPJOHN, CO.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=becf7b7a-508c-44ff-add0-558a60fd0067 | publisher =  | date =  | accessdate = }}</ref>


==References==
==References==

Revision as of 01:21, 24 December 2013

Spectinomycin
TROBICIN® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Overdosage
Dosage and Administration
How Supplied

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Microbiology

Spectinomycin hydrochloride is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit.

In vitro studies have shown spectinomycin hydrochloride to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Definitive in vitro studies have shown no cross-resistance of N. gonorrhoeae between spectinomycin hydrochloride and penicillin. The antibiotic is not significantly bound to plasma protein.[1]

References

  1. "TROBICIN (SPECTINOMYCIN) [PHARMACIA AND UPJOHN, CO.]".

Adapted from the FDA Package Insert.