Splenomegaly causes: Difference between revisions

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! Increased function
! Increased function
! Abnormal blood flow
! Abnormal blood flow
! Infitration
! Infiltration
|-
|-
| '''''Removal of defective RBCs'''''
| '''''Removal of defective RBCs'''''
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''Response to infection (viral,bacterial,fungal,parasitic'')<br />[[Mononucleosis]], [[AIDS]], [[viral hepatitis]]<br />subacute [[bacterial endocarditis]], bacterial [[septicemia]]<br /> splenic [[abscess]], [[typhoid fever]]<br />[[brucellosis]],[[ leptospirosis]], [[tuberculosis]]<br />[[histoplasmosis]]<br />[[malaria]], [[leishmaniasis]], [[trypanosomiasis]]<br />[[ehrlichiosis]]<br />''Disordered immunoregulation''<br />[[Rheumatoid arthritis]]<br />[[SLE]]<br />[[Serum sickness]]<br />[[Autoimmune hemolytic anemia]]<br />[[Idiopathic thrombocytopenic purpura|Immune thrombocytopenia]]<br />[[sarcoidosis]]<br />drug reactions<br />'''''Extramedullary hematopoiesis'''''<br />[[Myelofibrosis]]<br />Marrow infiltration by [[tumors]], [[leukemias]]<br />marrow damage by [[radiation]], [[toxins]]
''Response to infection (viral,bacterial,fungal,parasitic'')<br />[[Mononucleosis]], [[AIDS]], [[viral hepatitis]]<br />subacute [[bacterial endocarditis]], bacterial [[septicemia]]<br /> splenic [[abscess]], [[typhoid fever]]<br />[[brucellosis]],[[ leptospirosis]], [[tuberculosis]]<br />[[histoplasmosis]]<br />[[malaria]], [[leishmaniasis]], [[trypanosomiasis]]<br />[[ehrlichiosis]]<br />''Disordered immunoregulation''<br />[[Rheumatoid arthritis]]<br />[[SLE]]<br />[[Serum sickness]]<br />[[Autoimmune hemolytic anemia]]<br />[[Idiopathic thrombocytopenic purpura|Immune thrombocytopenia]]<br />[[sarcoidosis]]<br />drug reactions<br />'''''Extramedullary hematopoiesis'''''<br />[[Myelofibrosis]]<br />Marrow infiltration by [[tumors]], [[leukemias]]<br />marrow damage by [[radiation]], [[toxins]]
|'''''Organ Failure'''''<br />
|'''''Organ Failure'''''<br />
[[Cirrhosis]]<br />[[congestive heart failure]]<br />'''''Vascular'''''<br />[[hepatic vein obstruction]]<br />[[Portal vein thrombosis|portal vein obstruction]]<br />[[Budd-Chiari syndrome]]<br />[[splenic vein obstruction]]<br />'''''Infections'''''<br /><br />hepatic [[schistosomiasis]]<br />hepatic [[echinococcosis]]
[[Cirrhosis]]<br />[[congestive heart failure]]<br />'''''Vascular'''''<br />[[Hepatic vein obstruction]]<br />[[Portal vein thrombosis|Portal vein obstruction]]<br />[[Budd-Chiari syndrome]]<br />[[Splenic vein obstruction]]<br />'''''Infections'''''<br /><br />Hepatic [[schistosomiasis]]<br />Hepatic [[echinococcosis]]
  |'''''Metabolic diseases'''''<br />[[Gauchers disease]]<br />[[Niemann-Pick disease]]<br />[[Hurler syndrome]] and other [[Mucopolysaccharidoses]]<br />[[Amyloidosis]]<br />[[Tangier disease]]<br />'''''Benign and malignant infiltrations'''''<br />[[Leukemias]](acute,chronic,lymphoid and myeloid)<br />lymphomas([[Hodgkins]] and [[Non-Hodgkin lymphoma|non-hodgkins]])<br />[[myeloproliferative]] disorders<br />[[metastatic]] tumors(commonly [[melanoma]])<br />[[histiocytosis X]]<br />[[Hemangioma]],[[lymphangioma]]<br />splenic [[cysts]]<br />[[hamartomas]]<br />[[eosinophilic granuloma]]
  |'''''Metabolic diseases'''''<br />[[Gauchers disease]]<br />[[Niemann-Pick disease]]<br />[[Hurler syndrome]] and other [[Mucopolysaccharidoses]]<br />[[Amyloidosis]]<br />[[Tangier disease]]<br />'''''Benign and malignant infiltrations'''''<br />[[Leukemias]](acute,chronic,lymphoid and myeloid)<br />lymphomas([[Hodgkins]] and [[Non-Hodgkin lymphoma|non-hodgkins]])<br />[[myeloproliferative]] disorders<br />[[metastatic]] tumors(commonly [[melanoma]])<br />[[histiocytosis X]]<br />[[Hemangioma]],[[lymphangioma]]<br />splenic [[cysts]]<br />[[hamartomas]]<br />[[eosinophilic granuloma]]


Revision as of 19:46, 21 May 2013

Template:Splenomegaly Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Causes in Alphabetical Order

[1] [2]



Less common causes [3]

Causes by Organ System

Splenomegaly grouped on the basis of the pathogenic mechanism

Increased function Abnormal blood flow Infiltration
Removal of defective RBCs

Spherocytosis
Thalassemia
Hemoglobinopathies
Nutritional anemias
early sickle cell anemia
Immune hyperplasia
Response to infection (viral,bacterial,fungal,parasitic)
Mononucleosis, AIDS, viral hepatitis
subacute bacterial endocarditis, bacterial septicemia
splenic abscess, typhoid fever
brucellosis,leptospirosis, tuberculosis
histoplasmosis
malaria, leishmaniasis, trypanosomiasis
ehrlichiosis
Disordered immunoregulation
Rheumatoid arthritis
SLE
Serum sickness
Autoimmune hemolytic anemia
Immune thrombocytopenia
sarcoidosis
drug reactions
Extramedullary hematopoiesis
Myelofibrosis
Marrow infiltration by tumors, leukemias
marrow damage by radiation, toxins

Organ Failure

Cirrhosis
congestive heart failure
Vascular
Hepatic vein obstruction
Portal vein obstruction
Budd-Chiari syndrome
Splenic vein obstruction
Infections

Hepatic schistosomiasis
Hepatic echinococcosis

Metabolic diseases
Gauchers disease
Niemann-Pick disease
Hurler syndrome and other Mucopolysaccharidoses
Amyloidosis
Tangier disease
Benign and malignant infiltrations
Leukemias(acute,chronic,lymphoid and myeloid)
lymphomas(Hodgkins and non-hodgkins)
myeloproliferative disorders
metastatic tumors(commonly melanoma)
histiocytosis X
Hemangioma,lymphangioma
splenic cysts
hamartomas
eosinophilic granuloma

Causes of Massive Splenomegaly (>1000gms)

References

  1. ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
  3. ↑ Kahan, Scott, Smith, Ellen G. In a page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:157

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